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. 2022 Dec 20;38(4):334-344.
doi: 10.47717/turkjsurg.2022.5861. eCollection 2022 Dec.

Long-term results and prognostic factors after surgical treatment for gallbladder cancer

Mehmet Ali Uzun  1   2 , Metin Tilki  1 , Sevcan Alkan Kayaoğlu  1 , Gülten Çiçek Okuyan  1 , Zeynep Gamze Kılıçoğlu  3 , Aylin Gönültaş  4
Affiliations

Long-term results and prognostic factors after surgical treatment for gallbladder cancer

Mehmet Ali Uzun et al. Turk J Surg. .

Abstract

Objectives: Gallbladder cancer is relatively rare and traditionally regarded as having poor prognosis. There is controversy about the effects of clinicopathological features and different surgical techniques on prognosis. The aim of this study was to investigate the effects of clinicopathological characteristics of the patients with surgically treated gallbladder cancer on long-term survival.

Material and methods: We retrospectively analyzed the database of gallbladder cancer patients treated at our clinic between January 2003 and March 2021.

Results: Of 101 evaluated cases, 37 were inoperable. Twelve patients were determined unresectable based on surgical findings. Resection with curative intent was performed in 52 patients. The one-, three-, five-, and 10-year survival rates were 68.9%, 51.9%, 43.6%, and 43.6%, respectively. Median survival was 36.6 months. On univariate analysis, poor prognostic factors were determined as advanced age; high carbohydrate antigen 19-9 and carcinoembryonic antigen levels; non-incidental diagnosis; intraoperative incidental diagnosis; jaundice; adjacent organ/structure resection; grade 3 tumors; lymphovascular invasion; and high T, N1 or N2, M1, and high AJCC stages. Sex, IVb/V segmentectomy instead of wedge resection, perineural invasion, tumor location, number of resected lymph nodes, and extended lymphadenectomy did not significantly affect overall survival. On multivariate analysis, only high AJCC stages, grade 3 tumors, high carcinoembryonic antigen levels, and advanced age were independent predictors of poor prognosis.

Conclusion: Treatment planning and clinical decision-making for gallbladder cancer requires individualized prognostic assessment along with standard anatomical staging and other confirmed prognostic factors.

Keywords: Biliary tract surgical procedures; gallbladder neoplasm; prognostic factors; survival.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1. Kaplan-Meier survival curves of overall survival of patient
Figure 2
Figure 2. Kaplan-Meier survival curve of overall survival according to T stage (p< 0.001) (A), N stage (p< 0.001) (B), M stage (p= 0.012) (C), and American Joint Commission on Cancer stage (p< 0.001) (D).
See this image and copyright information in PMC

References

    1. Sharma A, Sharma KL, Gupta A, Yadav A, Kumar A. Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. World J Gastroenterol. 2017;23(22):3978–3998. doi: 10.3748/wjg.v23.i22.3978. - DOI - PMC - PubMed
    1. Hickman L, Contreras C. Gallbladder cancer: Diagnosis, surgical management, and adjuvant therapies. Surg Clin North Am. 2019;99(2):337–355. doi: 10.1016/j.suc.2018.12.008. - DOI - PubMed
    1. Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Kay M, et al., editors. AJCC cancer staging manual. New York: Springer International Publishing; 2017. Gallbladder; pp. 303–309.
    1. Creasy JM, Goldman DA, Gonen M, Dudeja V, O’Reilly EM, Abou-Alfa GK, et al. Evolution of surgical management of gallbladder carcinoma and impact on outcome: Results from two decades at a single-institution. HPB (Oxford) 2019;21(11):1541–1551. doi: 10.1016/j.hpb.2019.03.370. - DOI - PMC - PubMed
    1. Schauer RJ, Meyer G, Baretton G, Schildberg FW, Rau HG. Prognostic factors and long-term results after surgery for gallbladder carcinoma: A retrospective study of 127 patients. Langenbecks Arch Surg. 2001;386(2):110–117. doi: 10.1007/s004230000189. - DOI - PubMed

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