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Review
. 2023 Feb 16:11:1143532.
doi: 10.3389/fcell.2023.1143532. eCollection 2023.

Protein homeostasis in aging and cancer

Xiao-Qiong Chen  1 , Tao Shen  1 , Shao-Jun Fang  1 , Xiao-Min Sun  1 , Guo-Yu Li  1 , Yun-Feng Li  1
Affiliations
Review

Protein homeostasis in aging and cancer

Xiao-Qiong Chen et al. Front Cell Dev Biol. .

Abstract

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health.

Keywords: aging; autophagy-lysosomal system; cancer; molecular chaperones; protein homeostasis; ubiquitin-proteasome system.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of regulatory mechanisms of protein homeostasis. Long-term chronic stress (e.g., oxidative stress) is an important cause for the loss of protein homeostasis, however, the increase in the function of proteolytic system (i.e., ubiquitin-proteasome system and autophagy-lysosomal system) and repair system (i.e., molecular chaperones) can promote the maintenance of protein homeostasis.
See this image and copyright information in PMC

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