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Review
. 2023 Feb 15:11:1124615.
doi: 10.3389/fcell.2023.1124615. eCollection 2023.

A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Soudeh Ghafouri-Fard  1 , Atefeh Harsij  2 , Bashdar Mahmud Hussen  3 , Snur Rasool Abdullah  4 , Aria Baniahmad  5 , Mohammad Taheri  6   7 , Guive Sharifi  7
Affiliations
Review

A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Soudeh Ghafouri-Fard et al. Front Cell Dev Biol. .

Abstract

LncRNA prostate androgen-regulated transcript 1 (PART1) is an important lncRNA in the carcinogenesis whose role has been firstly unraveled in prostate cancer. Expression of this lncRNA is activated by androgen in prostate cancer cells. In addition, this lncRNA has a role in the pathogenesis intervertebral disc degeneration, myocardial ischemia-reperfusion injury, osteoarthritis, osteoporosis and Parkinson's disease. Diagnostic role of PART1 has been assessed in some types of cancers. Moreover, dysregulation of PART1 expression is regarded as a prognostic factor in a variety of cancers. The current review provides a concise but comprehensive summary of the role of PART1 in different cancers and non-malignant disorders.

Keywords: PART1; biomarker; cancer; diagnsotic marker; lncRNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The chromosomal location of the prostate androgen-regulated transcript 1 (PART1) was initially identified in PCa. The NCBI database reveals the existence of three transcripts: NR 024617.1 (2.5 kb), NR 028509.1 (5.9 kb), and NR 028508.1 (2.1 kb).
FIGURE 2
FIGURE 2
An illustration shows the different signaling pathways of PART1 lncRNA with its expression and function in different types of cancer.
FIGURE 3
FIGURE 3
An illustration depicts the roles of PART1 activation and silencing in tumor formation in xenograft models, as well as the signaling pathways involved.
See this image and copyright information in PMC

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