Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 15:11:1124615.
doi: 10.3389/fcell.2023.1124615. eCollection 2023.

A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Soudeh Ghafouri-Fard  1 , Atefeh Harsij  2 , Bashdar Mahmud Hussen  3 , Snur Rasool Abdullah  4 , Aria Baniahmad  5 , Mohammad Taheri  6   7 , Guive Sharifi  7
Affiliations
Review

A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Soudeh Ghafouri-Fard et al. Front Cell Dev Biol. .

Abstract

LncRNA prostate androgen-regulated transcript 1 (PART1) is an important lncRNA in the carcinogenesis whose role has been firstly unraveled in prostate cancer. Expression of this lncRNA is activated by androgen in prostate cancer cells. In addition, this lncRNA has a role in the pathogenesis intervertebral disc degeneration, myocardial ischemia-reperfusion injury, osteoarthritis, osteoporosis and Parkinson's disease. Diagnostic role of PART1 has been assessed in some types of cancers. Moreover, dysregulation of PART1 expression is regarded as a prognostic factor in a variety of cancers. The current review provides a concise but comprehensive summary of the role of PART1 in different cancers and non-malignant disorders.

Keywords: PART1; biomarker; cancer; diagnsotic marker; lncRNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The chromosomal location of the prostate androgen-regulated transcript 1 (PART1) was initially identified in PCa. The NCBI database reveals the existence of three transcripts: NR 024617.1 (2.5 kb), NR 028509.1 (5.9 kb), and NR 028508.1 (2.1 kb).
FIGURE 2
FIGURE 2
An illustration shows the different signaling pathways of PART1 lncRNA with its expression and function in different types of cancer.
FIGURE 3
FIGURE 3
An illustration depicts the roles of PART1 activation and silencing in tumor formation in xenograft models, as well as the signaling pathways involved.
See this image and copyright information in PMC

References

    1. Cao Y., Zhang R., Luo X., Yang Y. (2021). LncRNA PART1 promotes lung squamous cell carcinoma progression via miR-185-5p/Six1 axis. Hum. Exp. Toxicol. 40 (6), 960–976. PubMed PMID: 33300377. Epub 2020/12/11. eng. 10.1177/0960327120979032 - DOI - PubMed
    1. Chen S. C., Diao Y. Z., Zhao Z. H., Li X. L. (2020). Inhibition of lncRNA PART1 chemosensitizes wild type but not KRAS mutant NSCLC cells. Cancer Manag. Res. 12, 4453–4460. PubMed PMID: 32606939. Pubmed Central PMCID: PMC7293907. Epub 2020/07/02. eng. 10.2147/CMAR.S245257 - DOI - PMC - PubMed
    1. Chen Y., Zhou X., Huang C., Li L., Qin Y., Tian Z., et al. (2021). LncRNA PART1 promotes cell proliferation and progression in non-small-cell lung cancer cells via sponging miR-17-5p. J. Cell. Biochem. 122 (3-4), 315–325. PubMed PMID: 33368623. Epub 2020/12/29. eng. 10.1002/jcb.29714 - DOI - PubMed
    1. Chi L. M., Wang L. P., Jiao D. (2019). Identification of differentially expressed genes and long noncoding RNAs associated with Parkinson's disease. Park. Dis. 2019, 6078251. PubMed PMID: 30867898. Pubmed Central PMCID: PMC6379850. Epub 2019/03/15. eng. 10.1155/2019/6078251 - DOI - PMC - PubMed
    1. Cruickshank B. M., Wasson M. D., Brown J. M., Fernando W., Venkatesh J., Walker O. L., et al. (2021). LncRNA PART1 promotes proliferation and migration, is associated with cancer stem cells, and alters the miRNA landscape in triple-negative breast cancer. Cancers (Basel) 13 (11), 2644. PubMed PMID: 34072264. Pubmed Central PMCID: PMC8198907. Epub 2021/06/03. eng. 10.3390/cancers13112644 - DOI - PMC - PubMed

LinkOut - more resources