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Multicenter Study
. 2023 Jul 1;24(7):541-550.
doi: 10.1097/PCC.0000000000003216. Epub 2023 Mar 6.

Early Changes in Arterial Partial Pressure of Carbon Dioxide and Blood Pressure After Starting Extracorporeal Membrane Oxygenation in Children: Extracorporeal Life Support Organization Database Study of Neurologic Complications

Neel Shah  1 , Xilong Li  2 , Prashanth Shanmugham  3 , Eddy Fan  4 , Ravi R Thiagarajan  5 , Ramgopal Venkataraman  6 , Lakshmi Raman  3
Affiliations
Multicenter Study

Early Changes in Arterial Partial Pressure of Carbon Dioxide and Blood Pressure After Starting Extracorporeal Membrane Oxygenation in Children: Extracorporeal Life Support Organization Database Study of Neurologic Complications

Neel Shah et al. Pediatr Crit Care Med. .

Abstract

Objective: Neurologic complications in pediatric patients supported by extracorporeal membrane oxygenation (ECMO) are common and lead to morbidity and mortality; however, few modifiable factors are known.

Design: Retrospective study of the Extracorporeal Life Support Organization registry (2010-2019).

Setting: Multicenter international database.

Patients: Pediatric patients receiving ECMO (2010-2019) for all indications and any mode of support.

Interventions: None.

Measurements and main results: We investigated if early relative change in Pa co2 or mean arterial blood pressure (MAP) soon after starting ECMO was associated with neurologic complications. The primary outcome of neurologic complications was defined as a report of seizures, central nervous system infarction or hemorrhage, or brain death. All-cause mortality (including brain death) was used as a secondary outcome.Out of 7,270 patients, 15.6% had neurologic complications. Neurologic complications increased when the relative Pa co2 decreased by greater than 50% (18.4%) or 30-50% (16.5%) versus those who had a minimal change (13.9%, p < 0.01 and p = 0.046). When the relative MAP increased greater than 50%, the rate of neurologic complications was 16.9% versus 13.1% those with minimal change ( p = 0.007). In a multivariable model adjusting for confounders, a relative decrease in Pa co2 greater than 30% was independently associated with greater odds of neurologic complication (odds ratio [OR], 1.25; 95% CI, 1.07-1.46; p = 0.005). Within this group, with a relative decrease in Pa co2 greater than 30%, the effects of increased relative MAP increased neurologic complications (0.05% per BP Percentile; 95% CI, 0.001-0.11; p = 0.05).

Conclusions: In pediatric patients, a large decrease in Pa co2 and increase in MAP following ECMO initiation are both associated with neurologic complications. Future research focusing on managing these issues carefully soon after ECMO deployment can potentially help to reduce neurologic complications.

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Conflict of interest statement

Dr. Fan reports personal fees from ALung Technologies, and Aerogen, Baxter, GE Healthcare, Inspira, and Vasomune outside the submitted work. Dr. Li disclosed work for hire. Dr. Thiagarajan’s institution received funding from the United States Department of Defense; he received funding from the Society of Critical Care Medicine and the Extracorporeal Life Support Organization. Dr. Raman received support for article research from the Extracorporeal Life Support Organization. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Comment in

References

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