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. 2023 Mar 6;18(3):e0272381.
doi: 10.1371/journal.pone.0272381. eCollection 2023.

SCOPE: Surveillance of COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020

Sunesh Kumar  1 , Neerja Bhatla  1 , K Aparna Sharma  1 , Ramesh Agarwal  1 , Ankit Verma  1 , Vanamail Perumal  1 , Poonam Shiv Kumar  2 , B S Garg  2 , Shivaprasad S Goudar  3 , Yeshita V Pujar  3 , Avinash Kavi  3 , Vanita Suri  4 , Bharti Joshi  4 , Asmita Rathore  5 , Madhavi M Gupta  5 , Ajay Kumar  5 , Manju Puri  6 , Deepika Meena  6 , Sushma Nangia  6 , Renu Arora  7 , Sumitra Bachani  7 , Pratima Anand  7 , Shikha Seth  8 , Rakesh Gupta  8 , Rohini Sehgal  1 , Anubhuti Rana  1 , Archana Kumari  1 , Shainy P  1 , Kasturi Donimath  9 , Guruprasad Gowder  10 , Lakshmi Kedar  3 , Tushar Kar  11 , Sujata Mishra  12 , Chinmayi Joshi  3 , Yogendra Kabade  9 , Saroja Kamatar  10 , Saumya Nanda  11 , Vandana Mohapatra  13 , Janki Vellanki  13 , Sarita Agarwal  14 , Aparna Wahane Borkar  15 , Aruna Kumar  16 , Shabana Sultan  16 , Neha Gangane  2 , Pushpa Chaudhary  17 , Anoma Jayathilaka  18 , Neena Raina  18 , Priya Karna  17 ; SCOPE Study Group
Affiliations

SCOPE: Surveillance of COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020

Sunesh Kumar et al. PLoS One. .

Abstract

Objective: To determine the clinical manifestations, risk factors, treatment modalities and maternal outcomes in pregnant women with lab-confirmed COVID-19 and compare it with COVID-19 negative pregnant women in same age group.

Design: Multicentric case-control study.

Data sources: Ambispective primary data collection through paper-based forms from 20 tertiary care centres across India between April and November 2020.

Study population: All pregnant women reporting to the centres with a lab-confirmed COVID-19 positive result matched with controls.

Data quality: Dedicated research officers extracted hospital records, using modified WHO Case Record Forms (CRF) and verified for completeness and accuracy.

Statistical analysis: Data converted to excel files and statistical analyses done using STATA 16 (StataCorp, TX, USA). Odds ratios (ORs) with 95% confidence intervals (CI) estimated using unconditional logistic regression.

Results: A total of 76,264 women delivered across 20 centres during the study period. Data of 3723 COVID positive pregnant women and 3744 age-matched controls was analyzed. Of the positive cases 56·9% were asymptomatic. Antenatal complications like preeclampsia and abruptio placentae were seen more among the cases. Induction and caesarean delivery rates were also higher among Covid positive women. Pre-existing maternal co-morbidities increased need for supportive care. There were 34 maternal deaths out of the 3723(0.9%) positive mothers, while covid negative deaths reported from all the centres were 449 of 72,541 (0·6%).

Conclusion: Covid-19 infection predisposed to adverse maternal outcomes in a large cohort of Covid positive pregnant women as compared to the negative controls.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Patient recruitment flow chart.
Fig 2
Fig 2. Ethics approval.
See this image and copyright information in PMC

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