Use of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Liver Disease

doi:10.1161/CIRCULATIONAHA.122.063195

Editorial

. 2023 Mar 7;147(10):795-797.

doi: 10.1161/CIRCULATIONAHA.122.063195. Epub 2023 Mar 6.

Use of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Liver Disease

Theresa J Hydes^{1

2}, Gregory Y H Lip^{1

3

4}, Deirdre A Lane^{1

3

4}

Affiliations

¹ Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, UK (T.J.H., G.Y.H.L., D.A.L.).
² Liverpool University Hospitals National Health Service Foundation Trust, Aintree University Hospital, Lower Lane, UK (T.J.H.).
³ Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, UK (G.Y.H.L., D.A.L.).
⁴ Department of Clinical Medicine, Aalborg University, Denmark (G.Y.H.L., D.A.L.).

PMID: 36877772
DOI: 10.1161/CIRCULATIONAHA.122.063195

Editorial

Use of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Liver Disease

Theresa J Hydes et al. Circulation. 2023.

. 2023 Mar 7;147(10):795-797.

doi: 10.1161/CIRCULATIONAHA.122.063195. Epub 2023 Mar 6.

Authors

Theresa J Hydes^{1

2}, Gregory Y H Lip^{1

3

4}, Deirdre A Lane^{1

3

4}

Affiliations

¹ Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, UK (T.J.H., G.Y.H.L., D.A.L.).
² Liverpool University Hospitals National Health Service Foundation Trust, Aintree University Hospital, Lower Lane, UK (T.J.H.).
³ Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, UK (G.Y.H.L., D.A.L.).
⁴ Department of Clinical Medicine, Aalborg University, Denmark (G.Y.H.L., D.A.L.).

PMID: 36877772
DOI: 10.1161/CIRCULATIONAHA.122.063195

No abstract available

Keywords: Editorials; atrial fibrillation; chronic liver disease; direct-acting oral anticoagulants.

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Dataset described in

Comparative Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin in Patients With Atrial Fibrillation and Chronic Liver Disease: A Nationwide Cohort Study.
Lawal OD, Aronow HD, Shobayo F, Hume AL, Taveira TH, Matson KL, Zhang Y, Wen X. Lawal OD, et al. Circulation. 2023 Mar 7;147(10):782-794. doi: 10.1161/CIRCULATIONAHA.122.060687. Epub 2023 Feb 10. Circulation. 2023. PMID: 36762560

Cited by

Anticoagulation for Stroke Prevention in Patients with Atrial Fibrillation: A Review of the Literature and Current Guidelines.
Vyas V, Vyas V, Sharma A, Ashok Kumar P. Vyas V, et al. Rev Cardiovasc Med. 2025 Jun 26;26(6):39233. doi: 10.31083/RCM39233. eCollection 2025 Jun. Rev Cardiovasc Med. 2025. PMID: 40630456 Free PMC article. Review.
Risk of Adverse Events in Anticoagulated Patients With Atrial Fibrillation and Nonalcoholic Fatty Liver Disease.
Bucci T, Nabrdalik K, Baratta F, Pastori D, Pignatelli P, Hydes T, Alam U, Violi F, Lip GYH. Bucci T, et al. J Clin Endocrinol Metab. 2024 Dec 18;110(1):208-217. doi: 10.1210/clinem/dgae394. J Clin Endocrinol Metab. 2024. PMID: 38864452 Free PMC article.
Efficacy and Safety of Direct Oral Anticoagulants Compared to Vitamin K Antagonists for Atrial Fibrillation in Patients With Liver Cirrhosis: An Update Systematic Review and Meta-analysis.
Miranda MCR, Santos CKM, Barbosa GA, Menezes Júnior ADS. Miranda MCR, et al. J Clin Exp Hepatol. 2025 Jul-Aug;15(4):102534. doi: 10.1016/j.jceh.2025.102534. Epub 2025 Feb 25. J Clin Exp Hepatol. 2025. PMID: 40256444 Review.
Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with liver disease: a systematic review and meta-analysis.
Zhou Q, Liu X, Liu S, Gu Z, Wu Y, Yang Y, Tao Y, Wei M. Zhou Q, et al. Front Pharmacol. 2025 Jul 14;16:1620394. doi: 10.3389/fphar.2025.1620394. eCollection 2025. Front Pharmacol. 2025. PMID: 40727096 Free PMC article.
Recommendations for the safe use of direct oral anticoagulants in patients with cirrhosis based on a systematic review of pharmacokinetic, pharmacodynamic and safety data.
Diesveld MME, Pijnenburg DWMJ, Weersink RA, Barzel I, Drenth JPH, Lisman T, Metselaar HJ, Monster-Simons MH, Mulder MB, Okel E, Taxis K, Borgsteede SD. Diesveld MME, et al. Eur J Clin Pharmacol. 2024 Jun;80(6):797-812. doi: 10.1007/s00228-024-03648-y. Epub 2024 Mar 2. Eur J Clin Pharmacol. 2024. PMID: 38430266

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Use of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Liver Disease

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Use of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Liver Disease

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