Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May:68:100955.
doi: 10.1016/j.drup.2023.100955. Epub 2023 Mar 4.

Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide

Rafael Ceña-Diez  1 , Anna-Lena Spetz  2 , Anders Sönnerborg  3
Affiliations

Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide

Rafael Ceña-Diez et al. Drug Resist Updat. 2023 May.

Abstract

The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-am:ssON) showed synergistic antiviral activity against HIV-1 integrase-, protease- or reverse transcriptase drug resistant isolates, with over 95% reduction. The highest selectivity indexes were for integrase resistant isolates. WG-am:ssON can be a future option for treatment of HIV drug-resistant strains.

Keywords: Combination; Dipeptide; Drug resistance; HIV; INSTI; SsON; Synergy.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest A.-L.S. declare ownership in TIRmed Pharma having IPR related to ssON.

Publication types

MeSH terms

LinkOut - more resources