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Review
. 2023 May;128(10):1797-1806.
doi: 10.1038/s41416-023-02213-1. Epub 2023 Mar 6.

Liver transplantation in metastatic colorectal cancer: are we ready for it?

Javier Ros #  1   2 , Francesc Salva #  3 , Cristina Dopazo  4 , Daniel López  3 , Nadia Saoudi  3 , Iosune Baraibar  3 , Ramon Charco  4 , Josep Tabernero  3 , Elena Elez  3
Affiliations
Review

Liver transplantation in metastatic colorectal cancer: are we ready for it?

Javier Ros et al. Br J Cancer. 2023 May.

Erratum in

Abstract

Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of Oslo Score, and Fong Clinical Risk Score criteria.
See this image and copyright information in PMC

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