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Review
. 2023 Jan-Dec:22:15347354231159322.
doi: 10.1177/15347354231159322.

A Review of The Synergistic Effects of Curcumin with Proteasome Inhibitors in Multiple Myeloma Preclinical Models

Shaunak K Pandya  1 , Arati Pandya  2 , Ashley Larsen  1 , Krisstina Gowin  1
Affiliations
Review

A Review of The Synergistic Effects of Curcumin with Proteasome Inhibitors in Multiple Myeloma Preclinical Models

Shaunak K Pandya et al. Integr Cancer Ther. 2023 Jan-Dec.

Abstract

Proteasome inhibitors are the cornerstone of multiple myeloma treatment, but challenges still remain despite the increased survival rates. We conducted a review on the role of curcumin, a natural product, as an adjunct to bortezomib and carfilzomib in preclinical multiple myeloma models. Four studies reviewed showed enhanced anticancer effects when curcumin was combined with bortezomib compared to either treatment alone. Two additional studies showed similar results with carfilzomib. Synergistic mechanisms include inhibition of NF-kB, IL-6-induced signaling pathways, JNK pathway modulation, and increased cell cycle arrest.

Keywords: bortezomib; carfilzomib; curcumin; multiple myeloma.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram outlining the literature review and study retrieval.
Figure 2.
Figure 2.
Synergistic effects of curcumin and proteasome inhibitors on pathways involved in MM cells.
Figure 3.
Figure 3.
Synergism of proteasome inhibitors and curcumin.
See this image and copyright information in PMC

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