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. 2023 Feb;73(1):9-14.
doi: 10.1007/s13224-022-01684-1. Epub 2022 Aug 18.

Maternal Serum Vitamin E Levels and its Association with Cord Blood Telomere Length and Mitochondrial DNA Copy Number in Preterm Premature Rupture of Membranes

Rupa Kumari  1 , Amita Suneja  1 , Mohit Mehndiratta  2 , Kiran Guleria  1 , Rashmi Malik  1
Affiliations

Maternal Serum Vitamin E Levels and its Association with Cord Blood Telomere Length and Mitochondrial DNA Copy Number in Preterm Premature Rupture of Membranes

Rupa Kumari et al. J Obstet Gynaecol India. 2023 Feb.

Abstract

Background and objective: Oxidative stress is one of the pathophysiological factors of pPROM and Vit. E being antioxidant may have preventive role. Study was conducted to estimate maternal serum vitamin E levels and cord blood oxidative stress markers in pPROM cases.

Methods: This was a case-control study including 40 pPROM cases and 40 controls. Maternal serum vitamin E levels were measured at recruitment. Cord blood was collected at delivery for estimation of telomere length and mtDNA copy number as oxidative stress markers. Levels were compared using student's t test or Mann Whitney test. For correlation Pearson coefficient was used.

Results: Maternal serum vitamin E levels were normal in pPROM cases. Cord blood telomere length was more in pPROM than controls (428.99 ± 290.65 vs 322.35 ± 180.33) (p value 0.05). Cord blood mtDNA copy number was more in pPROM than controls (516.46 ± 443.55 vs 384.77 ± 328.27) (p value 0.13) though it was not significant. mtDNA copy number had negative correlation with Vit. E levels but it was statistically not significant (p value 0.49). There was no association of vitamin E levels with telomere length (p value 0.95).

Interpretation and conclusion: pPROM was not associated with vitamin E deficiency. There was insignificant oxidative stress in cord blood as measured by mtDNA copy number but cord blood telomere length measurement did not detect any oxidative stress in pPPROM cases.

Keywords: Telomere length; Vitamin E; mtDNA copy number; pPROM.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no potential conflict of interest.

Figures

Fig. 1
Fig. 1
Association of maternal serum vitamin E levels with cord blood telomere length in pPROM
Fig. 2
Fig. 2
Association of maternal serum vitamin E levels with cord blood mtDNA copy number in pPROM
See this image and copyright information in PMC

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