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. 2023 Jun;10(2):157-171.
doi: 10.15441/ceem.23.005. Epub 2023 Mar 7.

Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis

Myeong Namgung  1 , Chiwon Ahn  1 , Yeonkyung Park  2 , Il-Youp Kwak  3 , Jungguk Lee  3 , Moonho Won  1
Affiliations

Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis

Myeong Namgung et al. Clin Exp Emerg Med. 2023 Jun.

Abstract

Objective: To evaluate mortality from sepsis and septic shock in Korea during the past 10 years, we conducted a systematic review and meta-analysis.

Methods: We searched six databases for studies on mortality from sepsis and septic shock in adult patients. Primary outcomes were 28- or 30-day mortality and in-hospital mortality from sepsis and septic shock. To assess the risk of bias, we used the Newcastle-Ottawa Scale and Risk of Bias 2 tools. The protocol is registered in PROSPERO (No. CRD42022365739).

Results: A total of 61 studies were included. The mortality rates from sepsis and septic shock at 28 or 30 days were 22.7% (95% confidence interval [CI], 20.0%-25.6%; I2=89%) and 27.6% (95% CI, 22.3%-33.5%; I2=98%), respectively, according to the Sepsis-3 criteria. Furthermore, in accordance with the Sepsis-3 criteria, the in-hospital mortality rates were 28.1% (95% CI, 25.2%-31.1%; I2=87%) and 34.3% (95% CI, 27.2%-42.2%; I2=97%), respectively.

Conclusion: The mortality rates from sepsis and septic shock in Korea are high. In the case of septic shock, the in-hospital mortality rate is approximately 30%.

Keywords: Meta-analysis; Mortality; Republic of Korea; Sepsis; Septic shock.

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Conflict of interest statement

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Flowchart for included studies. KMbase, Korean Medical Database; KISS, Korean Studies Information Service System.
Fig. 2.
Fig. 2.
Forest plot for 28- or 30-day mortality from sepsis using the Sepsis-3 criteria. CI, confidence interval.
Fig. 3.
Fig. 3.
Forest plot for in-hospital mortality from sepsis using the Sepsis-3 criteria. CI, confidence interval.
Fig. 4.
Fig. 4.
Forest plot for 28- or 30-day mortality from septic shock using the Sepsis-3 criteria. CI, confidence interval.
Fig. 5.
Fig. 5.
Forest plot for in-hospital mortality from septic shock using the Sepsis-3 criteria. CI, confidence interval.
See this image and copyright information in PMC

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