Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Feb 23;73(3):556-558.
doi: 10.1136/gutjnl-2022-329165.

Significant underestimation of preventive effects in colorectal cancer screening trial

Thomas Heisser  1   2   3 , Michael Hoffmeister  4 , Hermann Brenner  4   5
Affiliations
Comment

Significant underestimation of preventive effects in colorectal cancer screening trial

Thomas Heisser et al. Gut. .
No abstract available

Keywords: COLORECTAL CANCER; ENDOSCOPY; SCREENING.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Cumulative incidence (A) cumulative numbers of colorectal cancers cases (B) and risk ratios (C, D) in the actual and simulated NordICC trial. COSIMO, Colorectal Cancer Multistate Simulation Model; CRC, colorectal cancer; NordICC, Nordic-European Initiative on Colorectal Cancer.
See this image and copyright information in PMC

Comment on

References

    1. Morgan E, Arnold M, Gini A, et al. . Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 2023;72:338–44. 10.1136/gutjnl-2022-327736 - DOI - PubMed
    1. Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ 2014;348:g2467. 10.1136/bmj.g2467 - DOI - PMC - PubMed
    1. Bretthauer M, Løberg M, Wieszczy P, et al. . Effect of colonoscopy screening on risks of colorectal cancer and related death. N Engl J Med 2022;387:1547–56. 10.1056/NEJMoa2208375 - DOI - PubMed
    1. Senore C, Riggi E, Armaroli P, et al. . Long-Term follow-up of the Italian flexible sigmoidoscopy screening trial. Ann Intern Med 2022;175:36–45. 10.7326/M21-0977 - DOI - PubMed
    1. Atkin W, Wooldrage K, Parkin DM, et al. . Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK flexible sigmoidoscopy screening randomised controlled trial. Lancet 2017;389:1299–311. 10.1016/S0140-6736(17)30396-3 - DOI - PMC - PubMed