A new path to alternative lengthening of telomeres?

Oren J Becher^{1

2

3}

Affiliations

¹ Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
² Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Editorial

Oren J Becher. Neuro Oncol. 2023.

. 2023 Jul 6;25(7):1343-1344.

doi: 10.1093/neuonc/noad054.

Oren J Becher^{1

2

3}

¹ Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
² Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

No abstract available

Comment on

Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.
Stundon JL, Ijaz H, Gaonkar KS, Kaufman RS, Jin R, Karras A, Vaksman Z, Kim J, Corbett RJ, Lueder MR, Miller DP, Guo Y, Santi M, Li M, Lopez G, Storm PB, Resnick AC, Waanders AJ, MacFarland SP, Stewart DR, Diskin SJ, Rokita JL, Cole KA. Stundon JL, et al. Neuro Oncol. 2023 Jul 6;25(7):1331-1342. doi: 10.1093/neuonc/noac278. Neuro Oncol. 2023. PMID: 36541551 Free PMC article.

1. Demanelis K, Jasmine F, Chen LS, et al. . Determinants of telomere length across human tissues. Science. 2020;369(6509). - PMC - PubMed
1. Gao J, Pickett HA.. Targeting telomeres: Advances in telomere maintenance mechanism-specific cancer therapies. Nat Rev Cancer. 2022;22(9):515–532. - PubMed
1. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR.. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med. 1997;3(11):1271–1274. - PubMed
1. Schwartzentruber J, Korshunov A, Liu XY, et al. . Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482(7384):226–231. - PubMed
1. Stundon JL, Ijaz H, Gaonkar KS, et al. . ALT in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline MMR variants. Neuro-Oncology. 2023;25(7): 1331–1342. - PMC - PubMed