Review

. 2023 Jul 1;48(7):484-497.

doi: 10.1139/apnm-2022-0276. Epub 2023 Mar 8.

Nutrition and immunity: perspectives on key issues and next steps

Carolyn L Dunbar¹, Harold M Aukema², Philip C Calder^{3

4}, Deanna L Gibson⁵, Sarah E Henrickson^{6

7}, Saad Khan^{8

9}, Geneviève Mailhot^{10

11}, Shirin Panahi^{12

13}, Fred K Tabung¹⁴, Mei Tom¹⁵, Julia E M Upton^{16

17}, Daniel A Winer^{8

9

18

19

20}, Catherine J Field¹

Affiliations

¹ Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
² Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.
³ School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
⁵ Department of Biology, Faculty of Science, Okanagan Campus, The University of British Columbia, Kelowna, BC, Canada.
⁶ Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁷ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁸ Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGHRI), University Health Network, Toronto, ON, Canada.
⁹ Department of Immunology, University of Toronto, Toronto, ON, Canada.
¹⁰ CHU Sainte-Justine Research Center, Montreal, QC, Canada.
¹¹ Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
¹² Department of Physical Education, Université Laval, Quebec City, QC, Canada.
¹³ Canadian Nutrition Society, Ottawa, ON, Canada.
¹⁴ Department of Internal Medicine, Division of Medical Oncology, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
¹⁵ Nutrition Service, Alberta Health Services, Edmonton, AB, Canada.
¹⁶ Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
¹⁷ Division of Immunology and Allergy, Department of Pediatrics, SickKids Food Allergy and Anaphylaxis Program, Hospital for Sick Children, Toronto, ON, Canada.
¹⁸ Buck Institute for Research on Aging, Novato, CA, USA.
¹⁹ Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
²⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

PMID: 36888970
DOI: 10.1139/apnm-2022-0276

Free article

Review

Nutrition and immunity: perspectives on key issues and next steps

Carolyn L Dunbar et al. Appl Physiol Nutr Metab. 2023.

Free article

. 2023 Jul 1;48(7):484-497.

doi: 10.1139/apnm-2022-0276. Epub 2023 Mar 8.

Authors

Affiliations

¹ Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
² Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.
³ School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
⁵ Department of Biology, Faculty of Science, Okanagan Campus, The University of British Columbia, Kelowna, BC, Canada.
⁶ Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁷ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁸ Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGHRI), University Health Network, Toronto, ON, Canada.
⁹ Department of Immunology, University of Toronto, Toronto, ON, Canada.
¹⁰ CHU Sainte-Justine Research Center, Montreal, QC, Canada.
¹¹ Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
¹² Department of Physical Education, Université Laval, Quebec City, QC, Canada.
¹³ Canadian Nutrition Society, Ottawa, ON, Canada.
¹⁴ Department of Internal Medicine, Division of Medical Oncology, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
¹⁵ Nutrition Service, Alberta Health Services, Edmonton, AB, Canada.
¹⁶ Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
¹⁷ Division of Immunology and Allergy, Department of Pediatrics, SickKids Food Allergy and Anaphylaxis Program, Hospital for Sick Children, Toronto, ON, Canada.
¹⁸ Buck Institute for Research on Aging, Novato, CA, USA.
¹⁹ Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
²⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

PMID: 36888970
DOI: 10.1139/apnm-2022-0276

Abstract

In January 2022, a group of experts came together to discuss current perspectives and future directions in nutritional immunology as part of a symposium organized by the Canadian Nutrition Society. Objectives included (1) creating an understanding of the complex interplay between diet and the immune system from infants through to older adults, (2) illustrating the role of micronutrients that are vital to the immune system, (3) learning about current research comparing the impact of various dietary patterns and novel approaches to reduce inflammation, autoimmune conditions, allergies, and infections, and (4) discussing select dietary recommendations aimed at improving disease-specific immune function. The aims of this review are to summarize the symposium and to identify key areas of research that require additional exploration to better understand the dynamic relationship between nutrition and immune function.

Keywords: COVID-19; dietary patterns; food allergy; inflammation; oxylipins; vitamin D.

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Conflict of interest statement

The authors declare there are no competing interests.

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Nutrition and immunity: perspectives on key issues and next steps

Affiliations

Nutrition and immunity: perspectives on key issues and next steps

Authors

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Abstract

Conflict of interest statement

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