Rejuvenating muscle stem cells with the glutathione system
- PMID: 36889277
- DOI: 10.1016/j.cmet.2023.02.009
Rejuvenating muscle stem cells with the glutathione system
Abstract
Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.Cell Metab. 2023 Mar 7;35(3):472-486.e6. doi: 10.1016/j.cmet.2023.02.001. Epub 2023 Feb 27. Cell Metab. 2023. PMID: 36854304 Free PMC article.
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