Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Mar 7;35(3):383-385.
doi: 10.1016/j.cmet.2023.02.012.

Putting aging on ICE

Bryan B Teefy  1 , Bérénice A Benayoun  2
Affiliations
Comment

Putting aging on ICE

Bryan B Teefy et al. Cell Metab. .

Abstract

A recent report by Yang et al. in Cell demonstrates that faithful DNA double-strand breaks and repair cycles phenocopy many aspects of aging in mice. Whether this progeroid phenotype is caused by a loss of epigenetic information remains to be conclusively determined.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors have no conflicts of interest.

Figures

Figure 1:
Figure 1:. The ICE mouse model recapitulates many aspects of aging.
The ICE system creates inducible double strand breaks at 20 unique sites in the mouse nuclear genome, that are repaired with minimal mutagenesis. ICE cells show age-related signatures in vitro and ICE mice phenocopy many aspects of aging in vivo. Aspects of ICE-induced phenotypes can be rescued with OSK (Oct4-Sox2-Klf4) transient overexpression. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Loss of epigenetic information as a cause of mammalian aging.
    Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Yang JH, et al. Cell. 2023 Jan 19;186(2):305-326.e27. doi: 10.1016/j.cell.2022.12.027. Epub 2023 Jan 12. Cell. 2023. PMID: 36638792 Free PMC article.

References

    1. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, and Kroemer G (2023). Hallmarks of aging: An expanding universe. Cell 186, 243–278. 10.1016/j.cell.2022.11.001. - DOI - PubMed
    1. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, et al. (2023). Loss of epigenetic information as a cause of mammalian aging. Cell 186, 305–326 e327. 10.1016/j.cell.2022.12.027. - DOI - PMC - PubMed
    1. Watada E, Li S, Hori Y, Fujiki K, Shirahige K, Inada T, and Kobayashi T (2020). Age-Dependent Ribosomal DNA Variations in Mice. Mol Cell Biol 40. 10.1128/MCB.00368-20. - DOI - PMC - PubMed
    1. Rieckher M, Garinis GA, and Schumacher B (2021). Molecular pathology of rare progeroid diseases. Trends Mol Med 27, 907–922. 10.1016/j.molmed.2021.06.011. - DOI - PubMed
    1. Hauer MH, and Gasser SM (2017). Chromatin and nucleosome dynamics in DNA damage and repair. Genes Dev 31, 2204–2221. 10.1101/gad.307702.117. - DOI - PMC - PubMed

Publication types

LinkOut - more resources