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Randomized Controlled Trial
. 2023 May;86(5):e120-e122.
doi: 10.1016/j.jinf.2023.03.004. Epub 2023 Mar 6.

Effect of calcifediol supplementation as add-on therapy on the immune repertoire in recipients of the ChAdOx1 nCoV-19 vaccine: A prospective open-label, placebo-controlled, clinical trial

Swati Bhat  1 , Liza Das  1 , Deep Maheshwari  1 , Darshan Badal  1 , Roman Sarkar  1 , Madhu Gupta  2 , Surinder Singh Pandav  3 , Bijaya Kumar Padhi  2 , Sanjay Kumar Bhadada  1 , Michael F Holick  4 , Pinaki Dutta  5 , Naresh Sachdeva  6 , Raman Kumar Marwaha  7
Affiliations
Randomized Controlled Trial

Effect of calcifediol supplementation as add-on therapy on the immune repertoire in recipients of the ChAdOx1 nCoV-19 vaccine: A prospective open-label, placebo-controlled, clinical trial

Swati Bhat et al. J Infect. 2023 May.
No abstract available

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Conflict of interest statement

Conflicts of interest Michael F. Holick: Grants from Solius Inc. and Carbogen-Amcis, Consultant Biogena Inc. and Solius Inc., Speaker's Bureau Sanofi Inc., Abbott Inc. All other authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
(A-C) Plasma 25(OH)D levels at baseline, 3rd month, and 6th month in SARS-CoV-2 unexposed, exposed, and 2nd dose subjects. (D-F) The lymphocyte proliferation indices of peripheral blood mononuclear cells co-cultured with SARS-CoV-2 S-protein peptide pool cocktail are shown in the representative subjects of all the groups. The selection of subjects was arbitrary. (G-I) The cytokine levels (IL6, IL10, and TGF-β) in the plasma derived from whole blood cultures stimulated with SARS-CoV-2 S-protein peptide pool are shown in the representative subjects in the SARS-CoV-2 unexposed group. The representative subjects with calcifediol supplementation had plasma 25(OH)D levels> 40 ng/ml. Data are represented as median, IQR and range with mean represented as a dot. [*] represents P = <0.05, [**] represents P = <0.01, [***] represents P = <0.001, [****] represents P = <0.0001.
See this image and copyright information in PMC

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