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Review
. 2023 Mar 8;23(1):154.
doi: 10.1186/s12884-023-05460-5.

Spontaneous skull base cerebrospinal fluid leak during pregnancy: a case report and review of the literature

Lauren Michelle  1 , Rebecca J Post  2   3 , Edward C Kuan  1 , Michael P Nageotte  4   5
Affiliations
Review

Spontaneous skull base cerebrospinal fluid leak during pregnancy: a case report and review of the literature

Lauren Michelle et al. BMC Pregnancy Childbirth. .

Abstract

Background: Idiopathic intracranial hypertension can lead to dural defects and spontaneous leakage of cerebrospinal fluid (CSF) from the skull base. Skull base CSF leaks are rarely reported in pregnancy but pose unique challenges for obstetricians and anesthesiologists.

Case presentation: A 31-year-old G4P1021 at 14 weeks developed debilitating headaches and CSF rhinorrhea. Brain imaging revealed a bony defect of the sphenoid sinus with a meningoencephalocele and a partially empty sella, consistent with CSF leakage from a skull base defect. The patient was neurologically stable without signs of meningitis; thus, management was focused on symptomatic alleviation. A planned cesarean section was performed at 38 weeks under spinal anesthesia. The patient had spontaneous marked improvement of her symptoms postpartum.

Conclusion: Pregnancy may exacerbate skull base CSF leaks, requiring careful management with a multidisciplinary team. Neuraxial anesthesia can safely be performed in pregnant individuals with spontaneous skull base CSF leakage, but further studies are needed to determine the safest mode of delivery in these patients.

Keywords: Case report; Cerebrospinal fluid leak; Idiopathic intracranial hypertension; Neuraxial anesthesia; Pregnancy; Rhinorrhea.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A & B Adjacent slices of a coronal T2-weight MRI showing a focal defect in the floor of the middle cranial fossa and a meningoencephalocele continuous with defect. C T2 axial view of the same findings
See this image and copyright information in PMC

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