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. 2023 Mar 3:11:e14949.
doi: 10.7717/peerj.14949. eCollection 2023.

MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review

Zainab Jamal Al Gashaamy  1 , Tiba Alomar  1 , Linah Al-Sinjary  1 , Mohammad Wazzan  1 , Musab Hamed Saeed  2   3 , Natheer H Al-Rawi  1
Affiliations

MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review

Zainab Jamal Al Gashaamy et al. PeerJ. .

Abstract

Background: The aim of this systematic review is to determine microRNAs (miRs) that are differently expressed between diseased pulpal and periapical tissues.

Design: This systematic review used PubMed, Scopus, EBSCO, ProQuest, Cochrane database as well as manual searching to extract studies from January 2012 up to February 2022.

Results: A total of 12 studies met the eligibility criteria were included. All selected studies were of case-control type. Twenty-four miRNAs associated with apical periodontitis, 11 were found to be upregulatedand 13 were downregulated. Four out of the 44 miRs associated with pulpal inflammation were upregulated, whereas forty were downregulated. Six miRs, namely hsa-miR-181b, hsa-miR-181c,hsa-miR-455-3p,hsa-miR-128-3p, hsa-miR199a-5p, and hsa-miR-95, exhibited considerable downregulation in both periapical and pulp tissues.

Conclusion: MiRs have been investigated for their role in pulpal and periapical biology and may be utilised in diagnostic and therapeutic purposes. Further investigations are required to determine why certain irreversible pulpitis situations progress to apical periodontitis and others do not, based on the various miR expressions. Moreover, clinical and laboratory trials are needed to support this theory.

Keywords: Apical periodontitis; Expression; Inflammation; Pulpitis; miRNA.

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Conflict of interest statement

The authors declare there are no competing interests.

Figures

Figure 1
Figure 1. Summary of the systematic review workflow using a PRISMA chart.
Figure 2
Figure 2. Summary of the Mirna differently expressed in periapical periodontitis and pulpal inflammation.
Figure 3
Figure 3. (A) Common signaling Pathways in pulpal and periapical lesions. (B) Common host response in apical area.
See this image and copyright information in PMC

References

    1. Al Rawi N, Elmabrouk N, Kou RA, Mkadmi S, Rizvi Z, Hamdoon Z. The role of differentially expressed salivary microRNA in oral squamous cell carcinoma. A systematic review. Archives of Oral Biology. 2021;125:105108. doi: 10.1016/j.archoralbio.2021.105108. - DOI - PubMed
    1. Aldridge S, Hadfield J. Introduction to miRNA profiling technologies and cross-platform comparison. Methods in Molecular Biology. 2012;822:19–31. doi: 10.1007/978-1-61779-427-8_2. - DOI - PubMed
    1. Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350–355. doi: 10.1038/nature02871. - DOI - PubMed
    1. Bartel DP. MiroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;16(2):281–297. - PubMed
    1. Belibasakis GN, Rechenberg DK, Zehnder M. The receptor activator of NF-κ B ligand-osteoprotegerin system in pulpal and periapical disease. International Endodontic Journal. 2013;46(2):99–111. doi: 10.1111/j.1365-2591.2012.02105.x. - DOI - PubMed

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