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Review
. 2023 Feb 20:14:1140774.
doi: 10.3389/fendo.2023.1140774. eCollection 2023.

Endometriosis and dysbiosis: State of art

Brunella Zizolfi  1 , Virginia Foreste  1 , Alessandra Gallo  1 , Simona Martone  2 , Peirluigi Giampaolino  1 , Attilio Di Spiezio Sardo  1
Affiliations
Review

Endometriosis and dysbiosis: State of art

Brunella Zizolfi et al. Front Endocrinol (Lausanne). .

Abstract

Endometriosis is a complex and heterogeneous disease affecting approximately 10% of reproductive age women. The hypothesis that alterations in the microbiota are involved in the pathogenesis of endometriosis has been postulated. Possible explanations for the implications of dysbiosis in endometriosis include the Bacterial Contamination hypothesis and immune activation, cytokine-impaired gut function, altered estrogen metabolism and signaling. Thus, dysbiosis, disrupt normal immune function, leading to the elevation of proinflammatory cytokines, compromised immunosurveillance and altered immune cell profiles, all of which may contribute to the pathogenesis of endometriosis. The aim of this review is to summarize the available literature data about the relationship between microbiota and endometriosis.

Keywords: dysbiosis; endometriosis; estrobolome; infertility; microbiota.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AC declared a shared affiliation with the authors BZ, VF, AG, and AS to the handling editor at the time of review.

References

    1. Giudice LC. Endometriosis. N Engl J Med (2010) 362:2389–98. doi: 10.1056/NEJMcp1000274 - DOI - PMC - PubMed
    1. Practice Committee of the American Society for Reproductive Medicine . Endometriosis and infertility. Fertil Steril (2004) 81(5):1441–6. doi: 10.1016/j.fertnstert.2004.01.019 - DOI - PubMed
    1. Machairiotis N, Stylianaki A, Dryllis G, Zarogoulidis P, Kouroutou P, Tsiamis N, et al. . Extrapelvic endometriosis: A rare entity or an under diagnosed condition? Diagn Pathol (2013) 8(1):194. doi: 10.1186/1746-1596-8-194 - DOI - PMC - PubMed
    1. Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. Endometriosis. Nat Rev Dis.Primers (2018) 4:9. doi: 10.1038/s41572-018-0008-5 - DOI - PubMed
    1. Galvankar M, Singh N, Modi D. Estrogen is essential but not sufficient to induce endometriosis. J Biosci (2017) 42:251–63. doi: 10.1007/s12038-017-9687-4 - DOI - PubMed