Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;37(7):e14954.
doi: 10.1111/ctr.14954. Epub 2023 Mar 16.

Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference

Michelle T Jesse  1 , Whitney E Jackson  2 , AnnMarie Liapakis  3 , Swaytha Ganesh  4 , Abhinav Humar  4 , Nicolas Goldaracena  5 , Josh Levitsky  6 , David Mulligan  7 , Elizabeth A Pomfret  8 , Daniela P Ladner  6 , John P Roberts  9 , Alisha Mavis  10 , Carrie Thiessen  11 , James Trotter  12 , Gerald Scott Winder  13 , Adam D Griesemer  14 , Anjana Pillai  15 , Vineeta Kumar  16 , Elizabeth C Verna  17 , Dianne LaPointe Rudow  18 , Hyosun H Han  19 ; AST LDLT Consensus Conference Working Group
Affiliations

Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference

Michelle T Jesse et al. Clin Transplant. 2023 Jul.

Abstract

Introduction: Living donor liver transplantation (LDLT) is a promising option for mitigating the deceased donor organ shortage and reducing waitlist mortality. Despite excellent outcomes and data supporting expanding candidate indications for LDLT, broader uptake throughout the United States has yet to occur.

Methods: In response to this, the American Society of Transplantation hosted a virtual consensus conference (October 18-19, 2021), bringing together relevant experts with the aim of identifying barriers to broader implementation and making recommendations regarding strategies to address these barriers. In this report, we summarize the findings relevant to the selection and engagement of both the LDLT candidate and living donor. Utilizing a modified Delphi approach, barrier and strategy statements were developed, refined, and voted on for overall barrier importance and potential impact and feasibility of the strategy to address said barrier.

Results: Barriers identified fell into three general categories: 1) awareness, acceptance, and engagement across patients (potential candidates and donors), providers, and institutions, 2) data gaps and lack of standardization in candidate and donor selection, and 3) data gaps regarding post-living liver donation outcomes and resource needs.

Conclusions: Strategies to address barriers included efforts toward education and engagement across populations, rigorous and collaborative research, and institutional commitment and resources.

Keywords: living donor liver transplant; living donor transplant recipient; living liver donor.

PubMed Disclaimer

References

REFERENCES

    1. Rana A, Gruessner A, Agopian VG, et al. Survival benefit of solid-organ transplant in the United States. JAMA Surg. 2015;150:252-259.
    1. Yang LS, Shan LL, Saxena A, Morris DL. Liver transplantation: a systematic review of long-term quality of life. Liver Int. 2014;34:1298-1313.
    1. Kardashian A, Ge J, McCulloch CE, et al. Identifying an optimal liver frailty index cutoff to predict waitlist mortality in liver transplant candidates. Hepatology. 2021;73:1132-1139.
    1. Lai JC, Covinsky KE, Dodge JL, et al. Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017;66:564-574.
    1. Cullaro G, Sarkar M, Lai JC. Sex-based disparities in delisting for being “too sick” for liver transplantation. Am J Transplant. 2018;18:1214-1219.

Publication types

LinkOut - more resources