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Comment
. 2023 Jun;64(6):968-971.
doi: 10.1111/jcpp.13778. Epub 2023 Mar 9.

Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022)

Salahudeen Mirza  1   2 , Anna R Docherty  3   4   5 , Eric T Monson  3   4 , Hilary Coon  3   4 , Brooks Keeshin  3   4   6 , Gabriel R Fries  2   7   8
Affiliations
Comment

Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022)

Salahudeen Mirza et al. J Child Psychol Psychiatry. 2023 Jun.

Abstract

Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene-environment interactions across the life course. Lannoy et al. (Journal of Child Psychology and Psychiatry, 63, 2022 and 1164) describe a study in which polygenic risk for suicide attempt, as well as recent negative life events, were related to recent suicidal ideation in adolescents of about 17 years old. Building on this important work, we highlight several critical areas of focus for research in suicide genetics, including problems of measurement, as well as priorities for better uncovering the specific aetiological pathways to STB.

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References

    1. Brent, D.A., Bridge, J., Johnson, B.A., & Connolly, J. (1996). Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Archives of General Psychiatry, 53, 1145-1152.
    1. Burr, E.M., Rahm-Knigge, R.L., & Conner, B.T. (2018). The differentiating role of state and trait hopelessness in suicidal ideation and suicide attempt. Archives of Suicide Research, 22, 510-517.
    1. Facts About Suicide. (2022). Available from: https://www.cdc.gov/suicide/facts/index.html. Accessed February 28, 2023.
    1. Lannoy, S., Mars, B., Heron, J., & Edwards, A.C. (2022). Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year. Journal of Child Psychology and Psychiatry, 63, 1164-1173.
    1. Lee, P.H., Doyle, A.E., Silberstein, M., Jung, J.-Y., Liu, R., Perlis, R.H., … & Kessler, R.C. (2022). Associations between genetic risk for adult suicide attempt and suicidal behaviors in young children in the US. JAMA Psychiatry, 79, 971-980.

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