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Observational Study
. 2023 Mar 9;38(1):64.
doi: 10.1007/s00384-023-04358-0.

Five-year follow-up mortality prognostic index for colorectal patients

Miren Orive  1   2   3 , Irantzu Barrio  4   5 , Santiago Lázaro  6   7 , Nerea Gonzalez  8   7   9   10 , Marisa Bare  11   7   9 , Nerea Fernandez de Larrea  12   13 , Maximino Redondo  14   7   9 , Sarai Cortajarena  4 , Amaia Bilbao  15   7   9 , Urko Aguirre  8   7   9 , Cristina Sarasqueta  16   7   9 , José M Quintana  8   7   9 ; REDISSEC-CARESS/CCR group
Affiliations
Observational Study

Five-year follow-up mortality prognostic index for colorectal patients

Miren Orive et al. Int J Colorectal Dis. .

Erratum in

Abstract

Purpose: To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient's health-related quality of life (HRQoL) status.

Methods: Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used.

Results: We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively.

Conclusions: These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.

Implications for cancer survivors: Patients with colorectal cancer should be monitored more closely depending on the severity of their disease and comorbidities as well as the perceived health-related quality of life, and preventive measures should be established to prevent adverse outcomes and therefore to ensure that better treatment is received.

Trial registration: ClinicalTrials.gov identifier: NCT02488161.

Keywords: Cohort studies; Colorectal cancer; Health-related quality of life; Patient-reported outcome measures; Survival models.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The Kaplan–Meier curves for the categorized risk score
See this image and copyright information in PMC

References

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