Microneedles: structure, classification, and application in oral cancer theranostics

doi:10.1007/s13346-023-01311-0

Review

. 2023 Sep;13(9):2195-2212.

doi: 10.1007/s13346-023-01311-0. Epub 2023 Mar 9.

Microneedles: structure, classification, and application in oral cancer theranostics

Xintong Li¹, Xi Xie¹, Yongzhi Wu¹, Zhuoyuan Zhang², Jinfeng Liao³

Affiliations

¹ State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
² Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. 407816983@qq.com.
³ State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. liaojinfeng.762@163.com.

PMID: 36892816
DOI: 10.1007/s13346-023-01311-0

Review

Microneedles: structure, classification, and application in oral cancer theranostics

Xintong Li et al. Drug Deliv Transl Res. 2023 Sep.

. 2023 Sep;13(9):2195-2212.

doi: 10.1007/s13346-023-01311-0. Epub 2023 Mar 9.

Authors

Xintong Li¹, Xi Xie¹, Yongzhi Wu¹, Zhuoyuan Zhang², Jinfeng Liao³

Affiliations

¹ State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
² Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. 407816983@qq.com.
³ State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. liaojinfeng.762@163.com.

PMID: 36892816
DOI: 10.1007/s13346-023-01311-0

Abstract

Oral cancer is a malignant tumor that threatens the health of individuals on a global scale. Currently available clinical treatment methods, including surgery, radiotherapy, and chemotherapy, significantly impact the quality of life of patients with systemic side effects. In the treatment of oral cancer, local and efficient delivery of antineoplastic drugs or other substances (like photosensitizers) to improve the therapy effect is a potential way to optimize oral cancer treatments. As an emerging drug delivery system in recent years, microneedles (MNs) can be used for local drug delivery, offering the advantages of high efficiency, convenience, and noninvasiveness. This review briefly introduces the structures and characteristics of various types of MNs and summarizes MN preparation methods. An overview of the current research application of MNs in different cancer treatments is provided. Overall, MNs, as a means of transporting substances, demonstrate great potential in oral cancer treatments, and their promising future applications and perspectives of MNs are outlined in this review.

Keywords: Diagnosis and therapy; Drug carrier; Microneedles; Oral cancer.

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References

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1. Nandini DB, Rao RS, Hosmani J, Khan S, Patil S, Awan KH. Novel therapies in the management of oral cancer: an update. Dis Mon. 2020;66(12):101036. https://doi.org/10.1016/j.disamonth.2020.101036 .
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[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin. 2021;71(3):209–249. https://doi.org/10.3322/caac.21660 .

[2] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin. 2021;71(3):209–249. https://doi.org/10.3322/caac.21660 .

[3] D’Souza W. Kumar A. microRNAs in oral cancer: moving from bench to bed as next generation medicine. Oral Oncol. 2020;111:104916. https://doi.org/10.1016/j.oraloncology.2020.104916 .

[4] D’Souza W. Kumar A. microRNAs in oral cancer: moving from bench to bed as next generation medicine. Oral Oncol. 2020;111:104916. https://doi.org/10.1016/j.oraloncology.2020.104916 .

[5] Nandini DB, Rao RS, Hosmani J, Khan S, Patil S, Awan KH. Novel therapies in the management of oral cancer: an update. Dis Mon. 2020;66(12):101036. https://doi.org/10.1016/j.disamonth.2020.101036 .

[6] Nandini DB, Rao RS, Hosmani J, Khan S, Patil S, Awan KH. Novel therapies in the management of oral cancer: an update. Dis Mon. 2020;66(12):101036. https://doi.org/10.1016/j.disamonth.2020.101036 .

[7] D'Cruz AK, Vaish R, Dhar H. Oral cancers: current status. Oral Oncol. 2018;8764–69. https://doi.org/10.1016/j.oraloncology.2018.10.013 .

[8] D'Cruz AK, Vaish R, Dhar H. Oral cancers: current status. Oral Oncol. 2018;8764–69. https://doi.org/10.1016/j.oraloncology.2018.10.013 .

[9] Ellis MA, Graboyes EM, Wahlquist AE, Neskey DM, Kaczmar JM, Schopper HK, Sharma AK, Morgan PF, Nguyen SA, Day TA. Primary surgery vs radiotherapy for early stage oral cavity cancer. Otolaryngol Head Neck Surg. 2018;158(4):649–659. https://doi.org/10.1177/0194599817746909 .

[10] Ellis MA, Graboyes EM, Wahlquist AE, Neskey DM, Kaczmar JM, Schopper HK, Sharma AK, Morgan PF, Nguyen SA, Day TA. Primary surgery vs radiotherapy for early stage oral cavity cancer. Otolaryngol Head Neck Surg. 2018;158(4):649–659. https://doi.org/10.1177/0194599817746909 .

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Microneedles: structure, classification, and application in oral cancer theranostics

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Microneedles: structure, classification, and application in oral cancer theranostics

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