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Review
. 2023 Sep;13(9):2195-2212.
doi: 10.1007/s13346-023-01311-0. Epub 2023 Mar 9.

Microneedles: structure, classification, and application in oral cancer theranostics

Xintong Li  1 , Xi Xie  1 , Yongzhi Wu  1 , Zhuoyuan Zhang  2 , Jinfeng Liao  3
Affiliations
Review

Microneedles: structure, classification, and application in oral cancer theranostics

Xintong Li et al. Drug Deliv Transl Res. 2023 Sep.

Abstract

Oral cancer is a malignant tumor that threatens the health of individuals on a global scale. Currently available clinical treatment methods, including surgery, radiotherapy, and chemotherapy, significantly impact the quality of life of patients with systemic side effects. In the treatment of oral cancer, local and efficient delivery of antineoplastic drugs or other substances (like photosensitizers) to improve the therapy effect is a potential way to optimize oral cancer treatments. As an emerging drug delivery system in recent years, microneedles (MNs) can be used for local drug delivery, offering the advantages of high efficiency, convenience, and noninvasiveness. This review briefly introduces the structures and characteristics of various types of MNs and summarizes MN preparation methods. An overview of the current research application of MNs in different cancer treatments is provided. Overall, MNs, as a means of transporting substances, demonstrate great potential in oral cancer treatments, and their promising future applications and perspectives of MNs are outlined in this review.

Keywords: Diagnosis and therapy; Drug carrier; Microneedles; Oral cancer.

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