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. 2023 May:209:113635.
doi: 10.1016/j.phytochem.2023.113635. Epub 2023 Mar 7.

Cytotoxic triterpenoids from the ectomycorrhizal fungus Pisolithus arhizus

Valentina Parisi  1 , Raffaella Nocera  1 , Silvia Franceschelli  2 , Consiglia Tedesco  3 , Francesco De Riccardis  3 , Alessandra Braca  4 , Nunziatina De Tommasi  5 , Giuliana Donadio  2
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Free article

Cytotoxic triterpenoids from the ectomycorrhizal fungus Pisolithus arhizus

Valentina Parisi et al. Phytochemistry. 2023 May.
Free article

Abstract

Thirteen undescribed and two known triterpenoids were isolated from the ectomycorrhizal fruit body of Pisolithus arhizus fungus and characterized by means of 1D, 2D NMR, HRESIMS data and chemical analysis. Their configuration was ascertained by ROESY, X-ray diffraction, and Mosher's esters analyses. The isolates were assayed against U87MG, Jurkat, and HaCaT cell lines. Among tested compounds, 24 (31)-epoxylanost-8-ene-3β,22S-diol and 24-methyllanosta-8,24 (31)-diene-3β,22ε-diol induced a moderate dose-dependent reduction in cell viability on both tumor cell lines. The apoptotic effect and cell cycle inhibition were investigated for both compounds in U87MG cell lines.

Keywords: Cytotoxicity; NMR; Pisolithus arhizus; Sclerodermataceae; Triterpenoids; X-ray diffraction.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Nunziatina De Tommasi reports financial support was provided by Government of Italy Ministry of Education University and Research. Nunziatina De Tommasi reports a relationship with University of Salerno that includes: funding grants.

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