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Editorial
. 2023 Jun;151(6):1474-1476.
doi: 10.1016/j.jaci.2023.02.027. Epub 2023 Mar 8.

Transgenerational epigenetic inheritance: Perspectives and challenges

Zhongzheng Niu  1 , Sahra Mohazzab-Hosseinian  1 , Carrie V Breton  2
Affiliations
Editorial

Transgenerational epigenetic inheritance: Perspectives and challenges

Zhongzheng Niu et al. J Allergy Clin Immunol. 2023 Jun.
No abstract available

Keywords: Transgenerational; asthma; environmental exposure; epigenetic; inheritance.

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Conflict of interest statement

Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.

Figures

FIG 1.
FIG 1.
Conceptual framework for transgenerational epigenetic inheritance. The traditional pathway (Path A) involves only inherited germline epimutation passing along generations. An alternative Path B involves parental somatic epimutation induced by grandparental germline epimutation. Parental somatic epimutation induces parental phenotypic changes that induce de novo parental germline epimutation. A germline epimutation, either inherited or de novo, could pass on to the offspring and the offspring disease phenotype. Confounding pathways involve shared environment.
See this image and copyright information in PMC

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