Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores

Michael Chong^#^{1

2

3

4}, Guillaume Paré^#^{5

6

7

8

9}

Affiliations

¹ Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
² Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
³ Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
⁴ Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
⁵ Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁶ Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁷ Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁸ Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁹ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.

^# Contributed equally.

Comment

Michael Chong et al. Nat Genet. 2023 Mar.

. 2023 Mar;55(3):358-360.

doi: 10.1038/s41588-023-01330-0.

Michael Chong^#^{1

2

3

4}, Guillaume Paré^#^{5

6

7

8

9}

¹ Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
² Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
³ Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
⁴ Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. michael.chong@crlb-gmel.ca.
⁵ Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁶ Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁷ Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁸ Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.
⁹ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. pareg@mcmaster.ca.

^# Contributed equally.

No abstract available

Comment on

Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism.
Ghouse J, Tragante V, Ahlberg G, Rand SA, Jespersen JB, Leinøe EB, Vissing CR, Trudsø L, Jonsdottir I, Banasik K, Brunak S, Ostrowski SR, Pedersen OB, Sørensen E, Erikstrup C, Bruun MT, Nielsen KR, Køber L, Christensen AH, Iversen K, Jones D, Knowlton KU, Nadauld L, Halldorsson GH, Ferkingstad E, Olafsson I, Gretarsdottir S, Onundarson PT, Sulem P, Thorsteinsdottir U, Thorgeirsson G, Gudbjartsson DF, Stefansson K, Holm H, Olesen MS, Bundgaard H. Ghouse J, et al. Nat Genet. 2023 Mar;55(3):399-409. doi: 10.1038/s41588-022-01286-7. Epub 2023 Jan 19. Nat Genet. 2023. PMID: 36658437

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