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. 2023 Feb 20:13:1094131.
doi: 10.3389/fonc.2023.1094131. eCollection 2023.

Association between small nucleolar RNA host gene expression and survival outcome of colorectal cancer patients: A meta-analysis based on PRISMA and bioinformatics analysis

Pei Luo  1 , Jie Du  2 , Yinan Li  2 , Jilong Ma  2 , Wenjun Shi  2
Affiliations

Association between small nucleolar RNA host gene expression and survival outcome of colorectal cancer patients: A meta-analysis based on PRISMA and bioinformatics analysis

Pei Luo et al. Front Oncol. .

Abstract

Introduction: Growing evidence shows that long non-coding RNA small nucleolar RNA host genes (lncRNA SNHGs) enact an pivotal regulatory roles in the shorter survival outcome of colorectal cancer (CRC). However, no research has systematically evaluated the correlation among lncRNA SNHGs expression and survival outcome of CRC. This research indented to screen whether exist potential prognostic effect of lncRNA SNHGs in CRC patientss using comprehensive review and meta-analysis.

Methods: Systematic searches were performed from the six relevant databases from inception to October 20, 2022. The quality of published papers was evaluated in details. We pooled the hazard ratios (HR) with 95% confidence interval (CI) through direct or indirect collection of effect sizes, and odds ratios (OR) with 95% CI by collecting effect sizes within articles. Detailed downstream signaling pathways of lncRNA SNHGs were summarized in detail.

Results: 25 eligible publications including 2,342 patients were finally included to appraise the association of lncRNA SNHGs with prognosis of CRC. Elevated lncRNA SNHGs expression was revealed in colorectal tumor tissues. High lncSNHG expression means bad survival prognosis in CRC patients (HR=1.635, 95% CI: 1.405-1.864, P<0.001). Additionally, high lncRNA SNHGs expression was inclined to later TNM stage (OR=1.635, 95% CI: 1.405-1.864, P<0.001), distant lymph node invasion, distant organ metastasis, larger tumor diameter and poor pathological grade. Begg's funnel plot test using the Stata 12.0 software suggested that no significant heterogeneity was found.

Conclusion: Elevated lncRNA SNHGs expression was revealed to be positively correlated to discontented CRC clinical outcome and lncRNA SNHG may act as a potential clinical prognostic index for CRC patients.

Keywords: SNHGs; bioinformatics analysis; colorectal cancer; lncRNA; meta-analysis; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the eligible studies.
Figure 2
Figure 2
Forest plot showing the relationship between small nucleolar RNA host gene expression and overall survival (OS) in colorectal cancers.
Figure 3
Figure 3
Forest plot showing the relationship between small nucleolar RNA host gene (SNHG) expression and progression-free survival (PFS) (A); disease-free survival (DFS) (B); and reference-free survival (RFS) in colorectal cancers (C).
Figure 4
Figure 4
Forest plot showing the relationship between small nucleolar RNA host gene (SNHG) expression and TNM stage in colorectal cancers.
Figure 5
Figure 5
Forest plot showing the relationship between small nucleolar RNA host gene (SNHG) expression and lymph node metastasis (LNM) stage in colorectal cancers.
Figure 6
Figure 6
Forest plot showing the relationship between small nucleolar RNA host gene (SNHG) expression and distant metastasis (DM) stage in colorectal cancers.
Figure 7
Figure 7
Forest plot showing the relationship between small nucleolar RNA host gene (SNHG) expression and tumor size stage in colorectal cancers.
Figure 8
Figure 8
Sensitivity analysis for small nucleolar RNA host gene expression with overall survival in colorectal cancers. HR, hazard ratio; CI, confidence interval.
Figure 9
Figure 9
Publication bias was explored using Begg’s test in colorectal cancers. (A) overall survival; (B) TNM stage; (C) lymph node metastasis; (D) distant metastasis; (E) tumor size; and (F) histological grade.
Figure 10
Figure 10
Expression levels of SNHG1-SNHG22 in colonic tumor and normal tissues in the GEPIA cohort by merging SNHG expression data (n=316).
Figure 11
Figure 11
Small nucleolar RNA host genes involved in a series of cellular biological roles in colorectal cancers.
See this image and copyright information in PMC

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