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Case Reports
. 2023 Feb 4;15(2):e34616.
doi: 10.7759/cureus.34616. eCollection 2023 Feb.

Use of ChatGPT in Academic Publishing: A Rare Case of Seronegative Systemic Lupus Erythematosus in a Patient With HIV Infection

Naveen Manohar  1 , Shruthi S Prasad  2
Affiliations
Case Reports

Use of ChatGPT in Academic Publishing: A Rare Case of Seronegative Systemic Lupus Erythematosus in a Patient With HIV Infection

Naveen Manohar et al. Cureus. .

Abstract

Diagnosing systemic lupus erythematosus (SLE) may be difficult in cases of negative results for antinuclear antibodies (ANAs) and anti-double stranded DNA (dsDNA) antibodies, which is known as seronegative SLE. Additionally, in patients with HIV infection, the diagnosis of SLE is made complicated by the overlap of symptoms and the possibility of false negative results on antibody tests. Herein, we report the case of a 24-year-old female with HIV infection on anti-retroviral therapy who presented with vesicles and plaques over the malar area and ulcers over the roof of the mouth. Antibody tests for ANAs and dsDNA were negative. She was initially treated for herpes simplex with a secondary infection, but the symptoms did not improve. She ultimately died from acute myocardial infarction while awaiting results of direct immunofluorescence, which revealed the deposition of immunoglobulin (Ig) M, IgG, and C3 along the basement membrane, thus enabling a diagnosis of SLE. Therefore, SLE can be difficult to diagnose in patients with HIV, and other diagnostic criteria should be considered when suspecting SLE and treating these patients. Additionally, we also present our experience with ChatGPT (OpenAI LP, OpenAI Inc., San Francisco, CA, USA) in academic publishing and its pros and cons.

Keywords: anti-retroviral therapy; antibodies; autoimmune; chatgpt; hiv; lupus; seronegative sle.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A 24-year-old female patient with HIV infection presented with red raised skin lesions for four months
Erythematous papules coalescing to form a crusted plaque noted over both malar areas and the nose.
Figure 2
Figure 2. Inspection of the oral cavity
Numerous erosions and ulcers are seen over the midline and lateral aspects of the oral mucosa with an erythematous base.
Figure 3
Figure 3. Cutaneous lesions over the hand
Several erythematous tiny ulcers are seen over the tips of the digits along with erythematous macules over the palms.
Figure 4
Figure 4. Initializing ChatGPT to help write this article using clear instructions
ChatGPT was able to generate text that was comprehensible and logical without glaring language errors.
Figure 5
Figure 5. Autogenerated list of references used by ChatGPT
The references are formatted as instructed as per the syntax that is generally used in medical academic publishing.
Figure 6
Figure 6. Letting ChatGPT state reasons why it should not be used in scientific publishing
The machine is able to provide three reasons, which are all valid and accurate. Additionally, it also includes an appropriate warning regarding its usage in academic publishing.
See this image and copyright information in PMC

Comment in

References

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