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. 2023 Feb 21:14:1131250.
doi: 10.3389/fneur.2023.1131250. eCollection 2023.

Stroke and the risk of gastrointestinal disorders: A Mendelian randomization study

Jingru Song  1 , Wenjing Chen  1 , Wei Ye  1
Affiliations

Stroke and the risk of gastrointestinal disorders: A Mendelian randomization study

Jingru Song et al. Front Neurol. .

Abstract

Background: The issue of whether a stroke is causally related to gastrointestinal disorders was still not satisfactorily understood. Therefore, we investigated if there is a connection between stroke and the most prevalent gastrointestinal disorders, including peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).

Methods: We applied two-sample Mendelian randomization to investigate relationships with gastrointestinal disorders. We obtained genome-wide association study (GWAS) summary data of any stroke, ischemic stroke, and its subtypes from the MEGASTROKE consortium. From the International Stroke Genetics Consortium (ISGC) meta-analysis, we acquired GWAS summary information on intracerebral hemorrhage (ICH), including all ICH, deep ICH, and lobar ICH. Several sensitivity studies were performed to identify heterogeneity and pleiotropy, while inverse-variance weighted (IVW) was utilized as the most dominant estimate.

Results: No evidence for an effect of genetic predisposition to ischemic stroke and its subtypes on gastrointestinal disorders were found in IVW. The complications of deep ICH are a higher risk for PUD and GERD. Meanwhile, lobar ICH has a higher risk of complications for PUD.

Conclusion: This study provides proof of the presence of a brain-gut axis. Among the complications of ICH, PUD and GERD were more common and associated with the site of hemorrhage.

Keywords: Mendelian randomization; causality; gastrointestinal disorders; risk; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Conceptual MR framework.
Figure 2
Figure 2
Bubble plot of MR study of stroke on gastrointestinal disorders derived from IVW.
Figure 3
Figure 3
Forest plot for the causal effect of stroke on the risk of gastrointestinal disorders. OR, odds ratio; CI, confidence interval.
See this image and copyright information in PMC

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