Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023:32:e01727.
doi: 10.1016/j.idcr.2023.e01727. Epub 2023 Mar 3.

Pneumococcal meningitis in a patient with severe COVID-19 on dexamethasone and tocilizumab: A case report

Affiliations
Case Reports

Pneumococcal meningitis in a patient with severe COVID-19 on dexamethasone and tocilizumab: A case report

Yoshiaki Murayama et al. IDCases. 2023.

Abstract

Although various therapeutic agents have been tried for coronavirus disease-2019 (COVID-19) and evidence has accumulated, the risk of secondary infection is increased by underlying disease and immunosuppressive drugs. We report a case of pneumococcal meningitis in a patient with severe COVID-19 who was receiving dexamethasone and tocilizumab. The patient's symptoms improved with appropriate diagnosis and antimicrobial therapy, and she fortunately returned to society without any neurological sequelae of meningitis.

Keywords: COVID-19; Meningitis; SARS-CoV-2; Secondary-infection; Streptococcus pneumoniae; Tocilizumab.

PubMed Disclaimer

Conflict of interest statement

The authors did not receive any specific grant from funding agencies in the public,commercial, or not-for-profit sectors.

Figures

Fig. 1
Fig. 1
Cerebrospinal fluid (CSF) The CSF was grossly thick.

References

    1. Information on COVID-19 treatment, prevention and research [Internet]. COVID-19 Treatment Guidelines. [cited 2022 April 20]. Available from: 〈〈https://www.covid19treatmentguidelines.nih.gov/〉〉.
    1. Langford Bradley J., So Miranda, Raybardhan Sumit, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26(12):1622–1629. doi: 10.1016/j.cmi.2020.07.016. - DOI - PMC - PubMed
    1. Russell Clark D., Fairfield Cameron J., Drake Thomas M., et al. Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. Lancet Microbe. 2021;2(8):e354–e365. doi: 10.1016/S2666-5247(21)00090-2. - DOI - PMC - PubMed
    1. The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med 384 (2021) 693–704 DOI: 10.1056/NEJMoa2021436

    1. Coomes Eric A., Haghbayan Hourmazd. Interleukin-6 in Covid-19: a systematic review and meta-analysis. Rev Med Virol. 2020;30:31–39. doi: 10.1002/rmv.2141. - DOI - PMC - PubMed

Publication types

LinkOut - more resources