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Editorial
. 2023 Feb:10.2217/fvl-2022-0181.
doi: 10.2217/fvl-2022-0181. Epub 2023 Mar 6.

Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike

Massimo Ciccozzi  1 , Stefano Pascarella  2
Affiliations
Editorial

Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike

Massimo Ciccozzi et al. Future Virol. 2023 Feb.

Abstract

The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.

Keywords: AXL; IntAct; N-terminal domain; SARS-CoV-2; Spike; allosteric interaction; electrostatic potential; indels; receptor binding domain; sialoside.

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Conflict of interest statement

Financial & competing interests disclosure S Pascarella is supported in part by the Sapienza Università di Roma grant (RP12117A7670A1E8). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed No writing assistance was utilized in the production of this manuscript.The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed

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