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Case Reports
. 2023 Feb 21:10:1025287.
doi: 10.3389/fsurg.2023.1025287. eCollection 2023.

Case report: Hilar metastasis of breast cancer: A single-center retrospective case-control study

Ruohan Yang  1 , Lin Jia  1 , Zheng Lv  1 , Jiuwei Cui  1
Affiliations
Case Reports

Case report: Hilar metastasis of breast cancer: A single-center retrospective case-control study

Ruohan Yang et al. Front Surg. .

Abstract

Purpose: The lungs are a common metastatic organ in breast cancer, mainly due to blood metastasis. On imaging, most metastatic lesions show a peripheral round mass in the lung, occasionally with a hilar mass as the primary manifestation, showing burr and lobulation signs. This study aimed to investigate breast cancer patient's clinical characteristics and prognosis with two different metastatic sites in the lung.

Methods: We retrospectively analyzed patients admitted to the First Hospital of Jilin University between 2016 and 2021 diagnosed with breast cancer lung metastases. Forty breast cancer patients with hilar metastases (HM) and 40 patients with peripheral lung metastases (PLM) were matched 1:1 using a pairing method. To analyze the patient's prognosis, the clinical characteristics of patients with two different metastatic sites were compared using the chi-square test, Kaplan-Meier curve, and Cox proportional hazards model.

Results: The median follow-up time was 38 months (2-91 months). The median age of patients with HM was 56 years (25-75 years), and that of patients with PLM was 59 years (44-82 years). The median overall survival (mOS) was 27 months in the HM group and 42 months in the PLM group (p = 0.001). The results of the Cox proportional hazards model showed that the histological grade (hazard ratio = 2.741, 95% confidence interval 1.442-5.208, p = 0.002) was a prognostic factor in the HM group.

Conclusion: The number of young patients in the HM group was higher than that in the PLM group, with higher Ki-67 indexes and histological grades. Most patients had mediastinal lymph node metastasis, with shorter DFI and OS and poor prognosis.

Keywords: breast cancer; hilar metastasis; overall survival; peripheral lung metastasis; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Imaging features of breast cancer patients with hilar metastasis (A–F): lung computed tomography images of three patients showed a single hilar mass with mediastinal lymphadenopathy.
Figure 2
Figure 2
Overall survival (OS) curves of patients with lung and hilar regions as the first metastatic sites.
Figure 3
Figure 3
Progression-free survival (PFS) curves of patients with lung and hilar regions as the first metastatic sites.
Figure 4
Figure 4
Overall survival (OS) curves for all patients in the hilar metastases (HM) and peripheral lung metastases (PLM) groups.
See this image and copyright information in PMC

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