doi: 10.1016/0005-2760(87)90065-8.
Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates
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- PMID: 3689819
- DOI: 10.1016/0005-2760(87)90065-8
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Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates
Biochim Biophys Acta.
.
Abstract
Chloroquine, when introduced into isolated perfused rat livers, caused a substantial output of cholesterol into bile, occurring after 30 min and peaking at 60 min, whereas the biliary output of acid phosphatase and beta-glucuronidase increased only after 90 min. The origins of this bile-salt-independent cholesterol are discussed.
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