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. 1987 Dec 14;922(3):395-7.
doi: 10.1016/0005-2760(87)90065-8.

Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates

K Rahman  1 , R Coleman
Affiliations

Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates

K Rahman et al. Biochim Biophys Acta. .

Abstract

Chloroquine, when introduced into isolated perfused rat livers, caused a substantial output of cholesterol into bile, occurring after 30 min and peaking at 60 min, whereas the biliary output of acid phosphatase and beta-glucuronidase increased only after 90 min. The origins of this bile-salt-independent cholesterol are discussed.

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