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. 2023 Mar 2;13(5):954.
doi: 10.3390/diagnostics13050954.

Blood Count-Derived Inflammatory Markers Correlate with Lengthier Hospital Stay and Are Predictors of Pneumothorax Risk in Thoracic Trauma Patients

Vlad Vunvulea  1   2   3 , Răzvan Marian Melinte  4 , Klara Brinzaniuc  3 , Bogdan Andrei Suciu  3 , Adrian Dumitru Ivănescu  3 , Ioana Hălmaciu  2   3 , Zsuzsanna Incze-Bartha  3 , Ylenia Pastorello  1   3 , Cristian Trâmbițaș  3 , Lucian Mărginean  1   2 , Réka Kaller  1   5 , Ahmad Kassas  6 , Timur Hogea  1
Affiliations

Blood Count-Derived Inflammatory Markers Correlate with Lengthier Hospital Stay and Are Predictors of Pneumothorax Risk in Thoracic Trauma Patients

Vlad Vunvulea et al. Diagnostics (Basel). .

Abstract

(1) Background: Trauma is one of the leading causes of death worldwide, with the chest being the third most frequent body part injured after abdominal and head trauma. Identifying and predicting injuries related to the trauma mechanism is the initial step in managing significant thoracic trauma. The purpose of this study is to assess the predictive capabilities of blood count-derived inflammatory markers at admission. (2) Materials and Methods: The current study was designed as an observational, analytical, retrospective cohort study. It included all patients over the age of 18 diagnosed with thoracic trauma, confirmed with a CT scan, and admitted to the Clinical Emergency Hospital of Targu Mureş, Romania. (3) Results: The occurrence of posttraumatic pneumothorax is highly linked to age (p = 0.002), tobacco use (p = 0.01), and obesity (p = 0.01). Furthermore, high values of all hematological ratios, such as the NLR, MLR, PLR, SII, SIRI, and AISI, are directly associated with the occurrence of pneumothorax (p < 0.001). Furthermore, increased values of the NLR, SII, SIRI, and AISI at admission predict a lengthier hospitalization (p = 0.003). (4) Conclusions: Increased neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), aggregate inflammatory systemic index (AISI), and systemic inflammatory response index (SIRI) levels at admission highly predict the occurrence of pneumothorax, according to our data.

Keywords: aggregate inflammatory systemic index; chest injury; inflammatory markers; monocyte-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; pneumothorax; systemic inflammatory index; systemic inflammatory response index; thoracic trauma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
ROC curve analysis concerning the pneumothorax risk: NLR (AUC: 0.798; p < 0.0001), MLR (AUC: 0.758; p < 0.0001), PLR (AUC: 0.714; p < 0.0001), SII (AUC: 0.807; p < 0.0001), SIRI (AUC: 0.799; p < 0.0001), and AISI (AUC: 0.799; p < 0.0001).
Figure 2
Figure 2
Plot representation of the dispersion of data of the association between length of hospital stay and the inflammatory biomarkers.
See this image and copyright information in PMC

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