Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 24;15(5):1452.
doi: 10.3390/cancers15051452.

Impact of Preventive Strategies on HPV-Related Diseases: Ten-Year Data from the Italian Hospital Admission Registry

Vincenzo Restivo  1 , Giuseppa Minutolo  1 , Marianna Maranto  2 , Antonio Maiorana  2 , Francesco Vitale  1 , Alessandra Casuccio  1 , Emanuele Amodio  1
Affiliations

Impact of Preventive Strategies on HPV-Related Diseases: Ten-Year Data from the Italian Hospital Admission Registry

Vincenzo Restivo et al. Cancers (Basel). .

Abstract

Human papillomavirus (HPV)-related diseases are still a challenge for public health. Some studies have shown the effects of preventive strategies on them, but studies at the national level are few in number. Therefore, a descriptive study through hospital discharge records (HDRs) was conducted in Italy between 2008 and 2018. Overall, 670,367 hospitalizations due to HPV-related diseases occurred among Italian subjects. In addition, a significant decrease in hospitalization rates for cervical cancer (average annual percentage change (AAPC) = -3.8%, 95% CI = -4.2, -3.5); vulval and vaginal cancer (AAPC = -1.4%, 95% CI = -2.2, -0.6); oropharyngeal cancer; and genital warts (AAPC = -4.0%, 95% CI = -4.5, -3.5) was observed during the study period. Furthermore, strong inverse correlations were found between screening adherence and invasive cervical cancer (r = -0.9, p < 0.001), as well as between HPV vaccination coverage and in situ cervical cancer (r = -0.8, p = 0.005). These results indicate the positive impact of HPV vaccination coverage and cervical cancer screening on hospitalizations due to cervical cancer. Indeed, HPV vaccination also resulted in a positive impact on the decrease in hospitalization rates due to other HPV-related diseases.

Keywords: HPV-related disease; Italy; cervical cancer; communication; effectiveness; healthcare workers; hospital admission; real world data; screening; vaccination.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Annual percentage change (APC) of hospitalization due to HPV-related diseases: (a) cervical cancer, (b) vulval and vaginal cancer, (c) penile cancer, (d) oropharyngeal cancer, (e) anal cancer, and (f) genital warts. * APC significantly different from 0 at the α = 0.05 level.
Figure 2
Figure 2
Average annual percent change (AAPC) of invasive cervical cancer trends in women’s classes of age and year regarding hospital admission, with related confidence intervals at 95%.
Figure 3
Figure 3
Average annual percent change (AAPC) of in situ cervical cancer trends understood via women’s classes of age and year of hospital admission, with related confidence intervals at 95%.
Figure 4
Figure 4
Correlation between hospitalization rates due to invasive cervical cancer and cervical cancer screening uptake with their respective average annual percent change (AAPC): (a) 2008–2018 AAPC = −2.8%, 95% CI = −3.2, −2.4, p < 0.001; (b) 2008–2018 AAPC = 0.5%, 95% CI = 0.2, 0.7, p < 0.001.
Figure 5
Figure 5
Correlation between hospitalization rates due to in situ cervical cancer and vaccination coverage against human papillomavirus (HPV), with their respective average annual percent change (AAPC): (a) 2008–2018 AAPC = −14.7%, 95% CI = −18.7, −10.5, p < 0.001; (b) 2009–2018 AAPC = 2.0%, 95% CI = 1.1, 2.9, p < 0.001.
See this image and copyright information in PMC

References

    1. De Brot L., Pellegrini B., Moretti S.T., Carraro D.M., Soares F.A., Rocha R.M., Baiocchi G., da Cunha I.W., de Andrade V.P. Infections with Multiple High-Risk HPV Types Are Associated with High-Grade and Persistent Low-Grade Intraepithelial Lesions of the Cervix. Cancer Cytopathol. 2017;125:138–143. doi: 10.1002/cncy.21789. - DOI - PubMed
    1. Okunade K.S. Human Papillomavirus and Cervical Cancer. J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol. 2020;40:602–608. doi: 10.1080/01443615.2019.1634030. - DOI - PMC - PubMed
    1. St Laurent J., Luckett R., Feldman S. HPV Vaccination and the Effects on Rates of HPV-Related Cancers. Curr. Probl. Cancer. 2018;42:493–506. doi: 10.1016/j.currproblcancer.2018.06.004. - DOI - PubMed
    1. Tang Y., Zheng L., Yang S., Li B., Su H., Zhang L.-P. Epidemiology and Genotype Distribution of Human Papillomavirus (HPV) in Southwest China: A Cross-Sectional Five Years Study in Non-Vaccinated Women. Virol. J. 2017;14:84. doi: 10.1186/s12985-017-0751-3. - DOI - PMC - PubMed
    1. Timbang M.R., Sim M.W., Bewley A.F., Farwell D.G., Mantravadi A., Moore M.G. HPV-Related Oropharyngeal Cancer: A Review on Burden of the Disease and Opportunities for Prevention and Early Detection. Hum. Vaccines Immunother. 2019;15:1920–1928. doi: 10.1080/21645515.2019.1600985. - DOI - PMC - PubMed

LinkOut - more resources