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Editorial
. 2023 Feb 28;15(5):1522.
doi: 10.3390/cancers15051522.

The Liver Cancer Immune Microenvironment: Emerging Concepts for Myeloid Cell Profiling with Diagnostic and Therapeutic Implications

Affiliations
Editorial

The Liver Cancer Immune Microenvironment: Emerging Concepts for Myeloid Cell Profiling with Diagnostic and Therapeutic Implications

Konstantinos Arvanitakis et al. Cancers (Basel). .

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide [...].

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Conflict of interest statement

All of the authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The role of neutrophils in the liver cancer immune microenvironment. CXCR2: C-X-C motif chemokine receptor 2; TAN: tumor-associated neutrophil; PD1: programmed cell death protein 1; CXCR2i: C-X-C motif chemokine receptor 2 inhibitor; NET: neutrophil extracellular trap; PD-L1: programmed death-ligand 1; ICI: immune checkpoint inhibitor; Treg: regulatory T; DC: dentritic cell; NK: natural killer.

References

    1. Foerster F., Gairing S.J., Ilyas S.I., Galle P.R. Emerging immunotherapy for HCC: A guide for hepatologists. Hepatology. 2022;75:1604–1626. doi: 10.1002/hep.32447. - DOI - PMC - PubMed
    1. Cheng A.L., Qin S., Ikeda M., Galle P.R., Ducreux M., Kim T.Y., Lim H.Y., Kudo M., Breder V., Merle P., et al. Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. J. Hepatol. 2022;76:862–873. doi: 10.1016/j.jhep.2021.11.030. - DOI - PubMed
    1. Anstee Q.M., Reeves H.L., Kotsiliti E., Govaere O., Heikenwalder M. From NASH to HCC: Current concepts and future challenges. Nat. Rev. Gastroenterol. Hepatol. 2019;16:411–428. doi: 10.1038/s41575-019-0145-7. - DOI - PubMed
    1. Pfister D., Nunez N.G., Pinyol R., Govaere O., Pinter M., Szydlowska M., Gupta R., Qiu M., Deczkowska A., Weiner A., et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature. 2021;592:450–456. doi: 10.1038/s41586-021-03362-0. - DOI - PMC - PubMed
    1. Muhammed A., Fulgenzi C.A.M., Dharmapuri S., Pinter M., Balcar L., Scheiner B., Marron T.U., Jun T., Saeed A., Hildebrand H., et al. The Systemic Inflammatory Response Identifies Patients with Adverse Clinical Outcome from Immunotherapy in Hepatocellular Carcinoma. Cancers. 2021;14:186. doi: 10.3390/cancers14010186. - DOI - PMC - PubMed

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