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. 2023 Feb 25;11(5):681.
doi: 10.3390/healthcare11050681.

Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes' Competitive Performance

Celal Bulgay  1 , Işık Bayraktar  2 , Hasan Huseyin Kazan  3 , Damla Selin Yıldırım  4 , Erdal Zorba  5 , Onur Akman  6 , Mehmet Ali Ergun  7 , Mesut Cerit  4 , Korkut Ulucan  8 , Özgür Eken  9 , Halil İbrahim Ceylan  10 , Georgian Badicu  11 , Wilhelm Robert Grosz  11 , Raluca Mijaică  11
Affiliations

Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes' Competitive Performance

Celal Bulgay et al. Healthcare (Basel). .

Abstract

The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes' performance. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/ physically inactive, aged 18-35, voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the athletes' personal best (PB). Whole exome sequencing (WES) was performed by the genomic DNA isolated from the peripheral blood of the participants. Sports type, sex, and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. The results showed no statistically significant difference between the CC, TC, and TT genotypes within and between the groups (p > 0.05). Additionally, our results underlined that there were no statistically significant differences for the association of rs2228570 polymorphism with PBs within the groups of the (p > 0.05) athletes. The genetic profile in the selected gene was similar in elite endurance, sprint athletes, and in controls, suggesting that rs2228570 polymorphism does not determine competitive performance in the analyzed athlete cohort.

Keywords: VDR; athletics; endurance athletes; rs2228570 polymorphism; sprint/power athletes.

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Conflict of interest statement

All authors declare having no conflict of interest.

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