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. 2023 Feb 24;20(5):4087.
doi: 10.3390/ijerph20054087.

Evidence from Human Studies for Utilising Cannabinoids for the Treatment of Substance-Use Disorders: A Scoping Review with a Systematic Approach

Kayvan Ali Gharbi  1   2 , Yvonne Ann Bonomo  2   3 , Christine Mary Hallinan  1   4
Affiliations

Evidence from Human Studies for Utilising Cannabinoids for the Treatment of Substance-Use Disorders: A Scoping Review with a Systematic Approach

Kayvan Ali Gharbi et al. Int J Environ Res Public Health. .

Abstract

Substance-use disorders are pervasive, comorbid with a plethora of disease and possess limited treatment options. Medicinal cannabinoids have been proposed as a novel potential treatment based on preclinical/animal trials. The objective of this study was to examine the efficacy and safety of potential therapeutics targeting the endocannabinoid system in the treatment of substance-use disorders. We performed a scoping review using a systematic approach of systematic reviews, narrative reviews, and randomised control trials that utilised cannabinoids as treatment for substance-use disorders. For this scoping review we used the PRISMA guidelines, a framework for systematic reviews and meta-analyses, to inform our methodology. We conducted a manual search of Medline, Embase, and Scopus databases in July 2022. Of the 253 results returned by the databases, 25 studies including reviews were identified as relevant, from which 29 randomised controlled trials were derived and analysed via a primary study decomposition. This review captured a small volume of highly heterogenous primary literature investing the therapeutic effect of cannabinoids for substance-use disorders. The most promising findings appeared to be for cannabis-use disorder. Cannabidiol appeared to be the cannabinoid showing the most promise for the treatment of multiple-substance-use disorders.

Keywords: cannabidiol; cannabinoids; dronabinol; substance-use disorders; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure A1
Figure A1
Search strategy.
Figure 1
Figure 1
PRISMA flow chart of narrative review search methods.
See this image and copyright information in PMC

References

    1. Australian Bureau of Statistics National Study of Mental Health and Wellbeing, 2020-21. [(accessed on 21 September 2022)]; Available online: https://www.abs.gov.au/statistics/health/mental-health/national-study-me....
    1. Kalin N.H. Substance Use Disorders and Addiction: Mechanisms, Trends, and Treatment Implications. Am. J. Psychiatry. 2020;177:1015–1018. doi: 10.1176/appi.ajp.2020.20091382. - DOI - PubMed
    1. Commission on Narcotic Drugs: 65th Session . Comorbidities in Drug Use Disorders: No Wrong Door. United Nations Office on Drugs and Crime; Vienna, Austria: 2022.
    1. Australian Institute of Health and Welfare Mental Health: Prevalence and Impact. [(accessed on 25 September 2022)];2022 Available online: https://www.aihw.gov.au/reports/mental-health-services/mental-health.
    1. National Institute on Drug Abuse Effective Treatments for Opioid Addiction. [(accessed on 16 September 2022)];2022 Available online: https://nida.nih.gov/publications/effective-treatments-opioid-addiction.

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