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Review
. 2023 Feb 28;24(5):4648.
doi: 10.3390/ijms24054648.

The Emerging Role of MMP12 in the Oral Environment

Bingpeng Lin  1   2   3 , Hooi Leng Ser  4 , Lijing Wang  1   5 , Jiang Li  1   2   3 , Kok-Gan Chan  6   7 , Learn-Han Lee  1   8 , Loh Teng-Hern Tan  1   8
Affiliations
Review

The Emerging Role of MMP12 in the Oral Environment

Bingpeng Lin et al. Int J Mol Sci. .

Abstract

Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.

Keywords: MMP12; OSCC; OTM; bone remodelling; periodontitis; tissue expression.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Violin plot of MMP12 expression in normal human tissues, coloured by organs. Bulk tissue gene expression for MMP12 from GTEx portal (https://gtexportal.org/home/gene/MMP12 (accessed on 25 March 2022)).
Figure 2
Figure 2
scRNA-Seq analysis of oral tissues from GEO datasets (GSE161266, GSE164241). The data used for this research were downloaded from online public database, and Seurat R package (version 4.0.2) was used for downstream analysis. (A) UMAP plot of the gingiva, periodontal ligament (Perio), and pulp tissues. (B) Violin plot of MMP12 expression in different cells of dental tissues, coloured by tissues.
Figure 3
Figure 3
The role of MMP12 in the oral environment and the proposed mechanisms of MMP12 in the pathologies of oral disorders, including periodontitis, temporomandibular joint dysfunction, and oral squamous cell carcinoma. The potential involvement of MMP12 in orthodontic tooth movement and bone remodelling is also included. This figure was created with the help of BioRender.com.
See this image and copyright information in PMC

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