Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 2;24(5):4819.
doi: 10.3390/ijms24054819.

Prevention of Ventriculostomy Related Infection: Effectiveness of Impregnated Biomaterial

Sylvain Diop  1 , Ariane Roujansky  2 , Hatem Kallel  2   3 , Roman Mounier  4   5
Affiliations
Review

Prevention of Ventriculostomy Related Infection: Effectiveness of Impregnated Biomaterial

Sylvain Diop et al. Int J Mol Sci. .

Abstract

External ventricular drain(EVD) exposes the patient to infectious complications which are associated with significant morbidity and economic burden. Biomaterials impregnated with various antimicrobial agents have been developed to decrease the rate of bacterial colonization and subsequent infection. While promising, antibiotics and silver-impregnated EVD showed conflicting clinical results. The aim of the present review is to discuss the challenges associated with the development of antimicrobial EVD catheters and their effectiveness from the bench to the bedside.

Keywords: antibiotics impregnated; bacteria; biofilm; biomaterial; external ventricular drain; silver nanoparticles.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Mojzsis S.J., Arrhenius G., McKeegan K.D., Harrison T.M., Nutman A.P., Friend C.R. Evidence for life on Earth before 3800 million years ago. Nature. 1996;384:55–59. doi: 10.1038/384055a0. - DOI - PubMed
    1. Beraldi-Campesi H. Early life on land and the first terrestrial ecosystems. Ecol. Process. 2013;2:1. doi: 10.1186/2192-1709-2-1. - DOI
    1. Reysenbach A.L., Ehringer M., Hershberger K. Microbial diversity at 83 degrees C in Calcite Springs, Yellowstone National Park: Another environment where the Aquificales and «Korarchaeota» coexist. Extrem. Life Extrem. Cond. 2000;4:61–67. - PubMed
    1. Brandwein M., Steinberg D., Meshner S. Microbial biofilms and the human skin microbiome. NPJ Biofilms Microbiomes. 2016;2:3. doi: 10.1038/s41522-016-0004-z. - DOI - PMC - PubMed
    1. Cho I., Blaser M.J. The human microbiome: At the interface of health and disease. Nat. Rev. Genet. 2012;13:260–270. doi: 10.1038/nrg3182. - DOI - PMC - PubMed

LinkOut - more resources