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. 1987 Nov 17;426(1):142-8.
doi: 10.1016/0006-8993(87)90433-1.

Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the Off pathway in the mudpuppy retina

M S Arkin  1 , R F Miller
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Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the Off pathway in the mudpuppy retina

M S Arkin et al. Brain Res. .

Abstract

The principal action of 2-amino-4-phosphonobutyrate (APB) applied to the retina is the elimination of the On-bipolar cell light response. In this study, we report that APB also has more subtle effects; it sometimes enhances Off responses of Off bipolar cells and On, Off, and On-Off inner retina neurons. Possible mechanisms for this enhancement are considered.

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