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Review
. 2023 Feb 23;28(5):2084.
doi: 10.3390/molecules28052084.

Microbial Hyaluronic Acid Production: A Review

Mónica Serra  1   2   3 , Ana Casas  1 , Duarte Toubarro  4 , Ana Novo Barros  1   5 , José António Teixeira  2   3
Affiliations
Review

Microbial Hyaluronic Acid Production: A Review

Mónica Serra et al. Molecules. .

Abstract

Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attention in recent years due to the increasing demand for this biopolymer for several industrial applications. Hyaluronic acid is a linear, non-sulfated glycosaminoglycan that is widely distributed in nature and is mainly composed of repeating units of N-acetylglucosamine and glucuronic acid. It has a wide and unique range of properties such as viscoelasticity, lubrication, and hydration, which makes it an attractive material for several industrial applications such as cosmetics, pharmaceuticals, and medical devices. This review presents and discusses the available fermentation strategies to produce hyaluronic acid.

Keywords: fermentation; hyaluronic acid; microbial production.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of HA adapted from [1].
See this image and copyright information in PMC

References

    1. Zhai P., Peng X., Li B., Liu Y., Sun H., Li X. The application of hyaluronic acid in bone regeneration. Int. J. Biol. Macromol. 2020;151:1224–1239. doi: 10.1016/j.ijbiomac.2019.10.169. - DOI - PubMed
    1. Necas J., Bartosikova L., Brauner P., Kolar J. Hyaluronic acid (hyaluronan): A review. Vet. Med. 2008;53:397–411. doi: 10.17221/1930-VETMED. - DOI
    1. Fallacara A., Baldini E., Manfredini S., Vertuani S. Hyaluronic acid in the third millennium. Polymers. 2018;10:701. doi: 10.3390/polym10070701. - DOI - PMC - PubMed
    1. Salwowska N.M., Bebenek K.A., Żądło D.A., Wcisło-Dziadecka D.L. Physiochemical properties and application of hyaluronic acid: A systematic review. J. Cosmet. Dermatol. 2016;15:520–526. doi: 10.1111/jocd.12237. - DOI - PubMed
    1. Liu L., Liu Y., Li J., Du G., Chen J. Microbial production of hyaluronic acid: Current state, challenges, and perspectives. Microb. Cell Fact. 2011;10:99. doi: 10.1186/1475-2859-10-99. - DOI - PMC - PubMed

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