Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 26;13(5):867.
doi: 10.3390/nano13050867.

A Nanotechnology-Based Approach to Biosensor Application in Current Diabetes Management Practices

Ambreen Shoaib  1 , Ali Darraj  2 , Mohammad Ehtisham Khan  3 , Lubna Azmi  4 , Abdulaziz Alalwan  5 , Osamah Alamri  6 , Mohammad Tabish  7 , Anwar Ulla Khan  8
Affiliations
Review

A Nanotechnology-Based Approach to Biosensor Application in Current Diabetes Management Practices

Ambreen Shoaib et al. Nanomaterials (Basel). .

Abstract

Diabetes mellitus is linked to both short-term and long-term health problems. Therefore, its detection at a very basic stage is of utmost importance. Research institutes and medical organizations are increasingly using cost-effective biosensors to monitor human biological processes and provide precise health diagnoses. Biosensors aid in accurate diabetes diagnosis and monitoring for efficient treatment and management. Recent attention to nanotechnology in the fast-evolving area of biosensing has facilitated the advancement of new sensors and sensing processes and improved the performance and sensitivity of current biosensors. Nanotechnology biosensors detect disease and track therapy response. Clinically efficient biosensors are user-friendly, efficient, cheap, and scalable in nanomaterial-based production processes and thus can transform diabetes outcomes. This article is more focused on biosensors and their substantial medical applications. The highlights of the article consist of the different types of biosensing units, the role of biosensors in diabetes, the evolution of glucose sensors, and printed biosensors and biosensing systems. Later on, we were engrossed in the glucose sensors based on biofluids, employing minimally invasive, invasive, and noninvasive technologies to find out the impact of nanotechnology on the biosensors to produce a novel device as a nano-biosensor. In this approach, this article documents major advances in nanotechnology-based biosensors for medical applications, as well as the hurdles they must overcome in clinical practice.

Keywords: biosensors; diabetes management; glucose biosensor; nanomaterials; nanotechnology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Biosensor for advanced biotechnology and research applications.
Figure 2
Figure 2
Diagnosis of glucose level in urine and blood with help of modern biosensor tools.
Figure 3
Figure 3
Illustration of glucose biosensor from the first to the third generation and its action on various biological fluids, such as urine, saliva, tear, and blood.
Figure 4
Figure 4
Nano-biosensors: Research focused on nanotechnology.
See this image and copyright information in PMC

References

    1. Amos A.F., McCarty D.J., Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med. 1997;14:S7–S85. doi: 10.1002/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.0.CO;2-R. - DOI - PubMed
    1. Rojas A., Lindner C., Gonzàlez I., Morales M.A. Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. World J. Diabetes. 2021;12:590. doi: 10.4239/wjd.v12.i5.590. - DOI - PMC - PubMed
    1. Gharravi A.M., Jafar A., Ebrahimi M., Mahmodi A., Pourhashemi E., Haseli N., Talaie N., Hajiasgarli P. Current status of stem cell therapy, scaffolds for the treatment of diabetes mellitus. Diabetes Metab. Syndr. Clin. Res. Rev. 2018;12:1133–1139. doi: 10.1016/j.dsx.2018.06.021. - DOI - PubMed
    1. Wise J. Type 1 Diabetes Is Still Linked to Lower Life Expectancy. British Medical Journal Publishing Group; London, UK: 2016. - PubMed
    1. Massaro J.D., Polli C.D., E Silva M.C., Alves C.C., Passos G.A., Sakamoto-Hojo E.T., de Holanda Miranda W.R., Cezar N.J.B., Rassi D.M., Crispim F. Post-transcriptional markers associated with clinical complications in Type 1 and Type 2 diabetes mellitus. Mol. Cell. Endocrinol. 2019;490:1–14. doi: 10.1016/j.mce.2019.03.008. - DOI - PubMed

LinkOut - more resources