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Review
. 2023 Feb 23;15(5):1107.
doi: 10.3390/nu15051107.

Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke-An Update

Salaheldin Abdelraouf Abdelsalam  1   2 , Kaviyarasi Renu  3 , Hamad Abu Zahra  1 , Basem M Abdallah  1 , Enas M Ali  1   4 , Vishnu Priya Veeraraghavan  3 , Kalaiselvi Sivalingam  5 , Larance Ronsard  6 , Rebai Ben Ammar  1   7 , Devanathadesikan Seshadri Vidya  8 , Palaniyandi Karuppaiya  9 , S Y Al-Ramadan  10 , Peramaiyan Rajendran  1   3
Affiliations
Review

Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke-An Update

Salaheldin Abdelraouf Abdelsalam et al. Nutrients. .

Abstract

Stroke is one of the main causes of mortality and disability, and it is due to be included in monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused by interference in cerebral blood flow, leading to a deficit in the supply of oxygen to the affected region. It accounts for nearly 80-85% of all cases of stroke. Oxidative stress has a significant impact on the pathophysiologic cascade in brain damage leading to stroke. In the acute phase, oxidative stress mediates severe toxicity, and it initiates and contributes to late-stage apoptosis and inflammation. Oxidative stress conditions occur when the antioxidant defense in the body is unable to counteract the production and aggregation of reactive oxygen species (ROS). The previous literature has shown that phytochemicals and other natural products not only scavenge oxygen free radicals but also improve the expressions of cellular antioxidant enzymes and molecules. Consequently, these products protect against ROS-mediated cellular injury. This review aims to give an overview of the most relevant data reported in the literature on polyphenolic compounds, namely, gallic acid, resveratrol, quercetin, kaempferol, mangiferin, epigallocatechin, and pinocembrin, in terms of their antioxidant effects and potential protective activity against ischemic stroke.

Keywords: epigallocatechin; gallic acid; ischemia stroke; kaempferol; mangiferin; oxidative stress; pinocembrin; quercetin; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Effects of gallic acid on ischemic stroke (image created using biorender.com (accessed on 21 October 2022)).
Figure 2
Figure 2
Effects of resveratrol on ischemic stroke (image created using biorender.com (accessed on 21 October 2022)).
Figure 3
Figure 3
Effects of quercetin on ischemic stroke (image created using biorender.com (accessed on 21 October 2022)).
Figure 4
Figure 4
Effects of kaempferol on ischemic stroke (image created using biorender.com (accessed on 21 October 2022)).
Figure 5
Figure 5
Effects of mangiferin, epigallocatechin, and pinocembrin on stroke.
See this image and copyright information in PMC

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