Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar;95(3):e28658.
doi: 10.1002/jmv.28658.

Viruses and phospholipids: Friends and foes during infection

Stephanie Rattay  1 , Martin Hufbauer  1 , Peter Hoboth  2   3 , Martin Sztacho  2 , Baki Akgül  1
Affiliations
Review

Viruses and phospholipids: Friends and foes during infection

Stephanie Rattay et al. J Med Virol. 2023 Mar.

Abstract

Viruses have evolved complex and dynamic interactions with their host cells to enable viral replication. In recent years, insights have been gained into the increasingly important role of the host cell lipidome in the life cycle of several viruses. In particular, viruses target phospholipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their replication cycle. Conversely, phospholipids and their associated regulatory enzymes can interfere with viral infection or replication. This review highlights examples of different viruses that illustrate the importance of these diverse virus-phospholipid interactions in different cellular compartments, particularly the role of nuclear phospholipids and their association with human papillomavirus (HPV)-mediated cancer development.

Keywords: phospholipids; virus host interactions; virus lipid interactions.

PubMed Disclaimer

References

REFERENCES

    1. Farías MA, Diethelm-Varela B, Navarro AJ, Kalergis AM, González PA. Interplay between lipid metabolism, lipid droplets, and DNA virus infections. Cells. 2022;11(14):2224.
    1. Beziau A, Brand D, Piver E. The role of phosphatidylinositol phosphate kinases during viral infection. Viruses. 2020;12(10):1124.
    1. Phan TK, Williams SA, Bindra GK, Lay FT, Poon IKH, Hulett MD. Phosphoinositides: multipurpose cellular lipids with emerging roles in cell death. Cell Death Differ. 2019;26(5):781-793.
    1. Fiume R, Faenza I, Sheth B, et al. Nuclear phosphoinositides: their regulation and roles in nuclear functions. Int J Mol Sci. 2019;20(12):2991.
    1. Saarikangas J, Zhao H, Lappalainen P. Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev. 2010;90(1):259-289.

Publication types

LinkOut - more resources