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. 2023 Aug;44(8):2811-2819.
doi: 10.1007/s10072-023-06675-2. Epub 2023 Mar 11.

Quantification of retinal ganglion cell loss in patients with homonymous visual field defect due to stroke

Stefania Bianchi Marzoli  1 , Lisa Melzi  2 , Paola Ciasca  2 , Alberto Raggi  3 , Anna Bersano  4 , Carlotta Casati  5 , Nadia Bolognini  6   7
Affiliations

Quantification of retinal ganglion cell loss in patients with homonymous visual field defect due to stroke

Stefania Bianchi Marzoli et al. Neurol Sci. 2023 Aug.

Abstract

Background: To quantify the degree of ganglion cell degeneration through spectral domain optical coherence tomography (SD-OCT) in adult patients with post-stroke homonymous visual field defect.

Methods: Fifty patients with acquired visual field defect due to stroke (mean age = 61 years) and thirty healthy controls (mean age = 58 years) were included. Mean deviation (MD) and pattern standard deviation (PSD), average peripapillary retinal nerve fibre layer thickness (pRNLF-AVG), average ganglion cell complex thickness (GCC-AVG), global loss volume (GLV) and focal loss volume (FLV) were measured. Patients were divided according to the damaged vascular territories (occipital vs. parieto-occipital) and stroke type (ischaemic vs. haemorrhagic). Group analysis was conducted with ANOVA and multiple regressions.

Results: pRNFL-AVG was significantly decreased among patients with lesions in parieto-occipital territories compared to controls and to patients with lesions in occipital territories (p = .04), with no differences with respect to stroke type. GCC-AVG, GLV and FLV differed in stroke patients and controls, regardless of stroke type and involved vascular territories. Age and elapsed time from stroke had a significant effect on pRNFL-AVG and GCC-AVG (p < .01), but not on MD and PSD.

Conclusions: Reduction of SD-OCT parameters occurs following both ischaemic and haemorrhagic occipital stroke, but it is larger when the injury extends to parietal territories and increases as time since stroke increases. The size of visual field defect is unrelated to SD-OCT measurements. Macular GCC thinning appeared to be more sensitive than pRNFL in detecting retrograde retinal ganglion cell degeneration and its retinotopic pattern in stroke.

Keywords: Ganglion cell complex thickness; Peripapillary retinal nerve fibre layer thickness; Retinal ganglion cell degeneration; Spectral domain optical coherence tomography; Stroke; Visual field defect.

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